A two-step hypothesis on the mechanisms of in vitro cell aging: Cell differentiation followed by intrinsic mitochondrial mutagenesis

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Mitochondrial role in cell aging

1980 • 919 citations

The interaction of closed circular DNA with intercalative dyes

1968 • 627 citations

Time, cells, and aging

1962 • 553 citations

Ethidium bromide induced mutation of yeast mitochondria: Complete transformation of cells into respiratory deficient non-chromosomal “petites”

1968 • 504 citations

Essays Upon Heredity and Kindred Biological Problems

2009 • 398 citations

The Turnover of Mitochondria in a Variety of Tissues of Young Adult and Aged Rats

1971 • 335 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Preferential alkylation of mitochondrial deoxyribonucleic acid by N-methyl-N-nitrosourea

1970 • 130 citations

Recent advances in the cell biology of aging

1980 • 106 citations

The Cellular Aging of Rat Fibroblasts <i>in vitro </i>Is a Differentiation Process

1979 • 77 citations

Fine structure of IMR-90 cells in culture as examined by scanning and transmission electron microscopy

1979 • 48 citations

Fate during cell growth of yeast mitochondrial and nuclear DNA after photolytic attachment of the monoazide analog of ethidium

1979 • 44 citations

Molecular Genetic Mechanisms in Development and Aging

1972 • 43 citations

The role of vitamin E in cellular energy metabolism in cultured adrenocortical cells

1982 • 35 citations

A concept of biological aging: The role of compensatory processes

1966 • 16 citations

Effect of x-irradiation on the hyaluronïdasehyaluronic acid system.

1951 • 8 citations