BCR-ABL Delays Apoptosis Upstream of Procaspase-3 Activation

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

The role of proteases during apoptosis

1996 • 558 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents

1995 • 363 citations

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

1993 • 238 citations

Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors

1994 • 208 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 195 citations

Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.

1986 • 191 citations

Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors

1993 • 169 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

1995 • 155 citations

The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.

1996 • 146 citations

Regulation of the Fas Apoptotic Cell Death Pathway by Abl

1995 • 146 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 145 citations

Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line.

1994 • 112 citations

The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors.

1995 • 107 citations

Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide.

1993 • 92 citations

The role of apoptosis in the pathogenesis and treatment of diseases

1996 • 81 citations

Antisense BCR-ABL oligonucleotides induce apoptosis in the Philadelphia chromosome-positive cell line BV173.

1994 • 77 citations

BCR-ABL does not prevent apoptotic death induced by human natural killer or lymphokine-activated killer cells

1996 • 62 citations

Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis.

1995 • 52 citations

bcr/abl expression in 32D cl3(G) cells inhibits apoptosis induced by protein tyrosine kinase inhibitors.

1994 • 50 citations

Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line

1995 • 50 citations

Phosphorothioate BCR-ABL antisense oligonucleotides induce cell death, but fail to reduce cellular bcr-abl protein levels.

1995 • 48 citations

v-Abl-mediated Apoptotic Suppression Is Associated with SHC Phosphorylation without Concomitant Mitogen-activated Protein Kinase Activation

1995 • 45 citations

The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.

1994 • 45 citations

Detection of apoptosis‐associated DNA fragmentation using a rapid and quantitative filter elution assay

1995 • 32 citations

Characterization of drug resistance mediated via the suppression of apoptosis by Abelson protein tyrosine kinase.

1995 • 30 citations

Regulation of apoptosis by oncogenes

1996 • 28 citations

Regulation of bone marrow myeloblast proliferation in chronic myeloid leukemia.

1976 • 28 citations

Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line.

1994 • 15 citations