Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

Investigation of exchange processes by two-dimensional NMR spectroscopy

1979 • 4,720 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Stereochemistry of polypeptide chain configurations

1963 • 3,351 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

1981 • 2,490 citations

Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains

1959 • 1,756 citations

Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame

1984 • 1,650 citations

Are there pathways for protein folding?

1968 • 1,496 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Specific Intermediates in the Folding Reactions of Small Proteins and the Mechanism of Protein Folding

1982 • 1,041 citations

Calibration of the angular dependence of the amide proton-Cα proton coupling constants, 3JHNα, in a globular protein

1984 • 956 citations

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

1987 • 930 citations

Nucleation, Rapid Folding, and Globular Intrachain Regions in Proteins

1973 • 826 citations

Polypeptide secondary structure determination by nuclear magnetic resonance observation of short proton-proton distances

1984 • 756 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 735 citations

Conformational Analysis of the 20 Naturally Occurring Amino Acid Residues Using ECEPP

1977 • 688 citations

Helix Signals in Proteins

1988 • 648 citations

Protein-folding dynamics

1976 • 626 citations

Tests of the helix dipole model for stabilization of α-helices

1987 • 598 citations

Sequential resonance assignments in protein 1H nuclear magnetic resonance spectra

1982 • 585 citations

Experimental studies of protein folding and unfolding

1979 • 535 citations

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

1984 • 485 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 437 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The formation and stabilization of protein structure

1972 • 372 citations

Stability of alpha-helices

1987 • 356 citations

Nature of the charged-group effect on the stability of the C-peptide helix.

1985 • 313 citations

Helix-coil transition of the isolated amino terminus of ribonuclease

1971 • 310 citations

Folding of Polypeptide Chains in Proteins: A Proposed Mechanism for Folding

1971 • 309 citations

A salt bridge stabilizes the helix formed by isolated C-peptide of RNase A.

1982 • 284 citations

The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn

1985 • 225 citations

Folding of Protein Fragments

1981 • 215 citations

Mechanisms of Antibody Binding to a Protein

1987 • 210 citations

A model of myoglobin self-organization

1975 • 207 citations

The Atomic Mobility Component of Protein Antigenicity

1985 • 201 citations

Is there a single pathway for the folding of a polypeptide chain?

1985 • 200 citations

Similarities of protein topologies: evolutionary divergence, functional convergence or principles of folding?

1980 • 194 citations

Antibodies of Predetermined Specificity in Biology and Medicine

1984 • 194 citations

A helix stop signal in the isolated S-peptide of ribonuclease A

1984 • 189 citations

A Method for Predicting Nucleation Sites for Protein Folding Based on Hydrophobic Contacts

1978 • 189 citations

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

1966 • 183 citations

Diffusion–collision model for protein folding

1979 • 183 citations

Hydrophobic basis of packing in globular proteins.

1980 • 175 citations

The influence of long-range interactions on the structure of myoglobin

1968 • 169 citations

Helix-coil stability constants for the naturally occurring amino acids in water. 22. Histidine parameters from random poly[(hydroxybutyl)glutamine-co-L-histidine]

1984 • 162 citations

Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix.

1987 • 160 citations

An Experimental Approach to the Study of the Folding of Staphylococcal Nuclease

1969 • 156 citations

Detection of an early intermediate in the folding of ribonuclease A by protection of amide protons against exchange

1979 • 154 citations

Folding units in globular proteins.

1981 • 141 citations

Use of amide ¹H‐nmr titration shifts for studies of polypeptide conformation

1979 • 133 citations

The Physical Basis for Induction of Protein-Reactive Antipeptide Antibodies

1988 • 130 citations

Protein folding kinetics by combined use of rapid mixing techniques and NMR observation of individual amide protons

1986 • 121 citations

The problem of how and why proteins adopt folded conformations

1985 • 115 citations

Molecular mapping of a histocompatibility-restricted immunodominant T cell epitope with synthetic and natural peptides: implications for T cell antigenic structure.

1986 • 105 citations

Compact units in proteins

1986 • 105 citations

Local interactions in bends of proteins.

1977 • 104 citations

Conformations of intermediates in the folding of the pancreatic trypsin inhibitor

1987 • 96 citations

Chain-folding initiation structures in ribonuclease A: conformational analysis of trans-Ac-Asn-Pro-Tyr-NHMe and trans-Ac-Tyr-Pro-Asn-NHMe in water and in the solid state

1984 • 87 citations

¹H NMR and CD evidence of the folding of the isolated ribonuclease 50–61 fragment

1987 • 80 citations

Seeding protein folding

1986 • 77 citations

A theory of protein molecule self-organization

1976 • 75 citations

Surface amino acids as sites of temperature-sensitive folding mutations in the P22 tailspike protein.

1988 • 74 citations

A novel approach for studies of the molecular conformations in flexible polypeptides

1974 • 68 citations

Hypothesis about the Mechanism of Protein Folding

1977 • 67 citations

Polypeptide chain folding through a highly helical intermediate as a general principle of globular protein structure formation

1978 • 66 citations

Thermodynamic parameters for the helix-coil thermal transition of ribonuclease-S-peptide and derivatives from¹H-nmr data

1986 • 65 citations

Folding of the nascent peptide chain into a biologically active protein

1988 • 64 citations

Investigation of the Conformations of Four Tetrapeptides by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopy, and Conformational Energy Calculations

1975 • 61 citations

Solution structure of the 45-residue magnesium ATP-binding peptide of adenylate kinase as examined by 2-D NMR, FTIR, and CD spectroscopy

1988 • 59 citations

¹H‐NMR assignment and secondary structure of a Herpes simplex virus glycoprotein D‐1 antigenic domain

1986 • 55 citations

Characterisation of a Local Structure in the Synthetic Parathyroid Hormone Fragment 1-34 by 1H Nuclear-Magnetic-Resonance Techniques

1978 • 54 citations

Monte Carlo simulations of the folding of beta-barrel globular proteins.

1988 • 51 citations

On the fundamental role of the glu 2−…Arg 10+ salt bridge in the folding of isolated ribonuclease a S-peptide

1984 • 50 citations

Intrinsic stabilities of portions of the ribonuclease molecule

1980 • 48 citations

Conformational unfolding in the N‐terminal region of ribonuclease a detected by nonradiative energy transfer: Distribution of interresidue distances in the native, denatured, and reduced‐denatured states

1988 • 47 citations

The Protein Folding Problem

1988 • 44 citations

Monte carlo studies on equilibrium globular protein folding. I. Homopolymeric lattice models of β‐barrel proteins

1987 • 44 citations

The C-peptide Helix from Ribonuclease A Considered as an Autonomous Folding Unit

1987 • 44 citations

Relative effects of primary and tertiary structure on helix formation in myoglobin and α-lactalbumin

1971 • 41 citations

Conformational studies of the synthetic fragment 1–34 of human parathyroid hormone by NMR techniques

1976 • 38 citations

Helical formation in isolated fragments of bovine growth hormone

1987 • 34 citations

A Circular Dichroic Spectral Study on Disuffide-Reduced Pancreatic Ribonuclease A and Its Renaturation to the Active Enzyme1

1977 • 33 citations

Location of an .alpha.-helix in fragment 96-133 from bovine somatotropin by proton NMR spectroscopy

1988 • 32 citations

Conformations of the glycine dipeptide

1987 • 28 citations

Microdomain dynamics in folding proteins

1982 • 23 citations

Alternative pathways in diffusion–collision controlled protein folding

1984 • 15 citations

Correlation between computed conformational properties of cytochrome c peptides and their antigenicity in a T‐lymphocyte proliferation assay

1987 • 7 citations

Nuclear overhauser effects as probes of peptide structure. A diagnostic for left-handed helical conformations

1987 • 6 citations

A Microbiological Method of Standardizing Liver Extracts

1947 • 5 citations