The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.

1977 • 2,233 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

In situ Hybridization

1994 • 875 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

1996 • 493 citations

Evidence from normal expression and targeted misexpression that Bone Morphogenetic Protein-4 (Bmp-4) plays a role in mouse embryonic lung morphogenesis

1996 • 480 citations

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/ fork head gene family, in the developing rat brain

1992 • 417 citations

A Homeodomain Protein Related to caudal Regulates Intestine-Specific Gene Transcription

1994 • 399 citations

Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes

1989 • 373 citations

Differentiation and self-renewal in the mouse gastrointestinal epithelium

1994 • 256 citations

Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.

1993 • 235 citations

The nucleotide sequence of rat liver fatty acid binding protein mRNA.

1983 • 235 citations

Molecular Aspects of Mesenchymal-Epithelial Interactions

1993 • 232 citations

Possible role of transforming growth factor α in the pathogenesis of Ménétrier's disease: Supportive evidence from humans and transgenic mice

1992 • 217 citations

Homeobox gene expression in the intestinal epithelium of adult mice.

1991 • 212 citations

The HNF-3 Gene Family of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution

1994 • 204 citations

A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

1988 • 202 citations

Cloning of a cDNA encoding rat intestinal fatty acid binding protein.

1984 • 198 citations

Homeotic genes and positional signalling in the Drosophila viscera

1994 • 180 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Wnt genes and vertebrate development

1994 • 173 citations

Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages

1994 • 153 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

Six members of the mouse forkhead gene family are developmentally regulated.

1993 • 144 citations

Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach.

1992 • 143 citations

The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head.

1993 • 110 citations

Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development

1996 • 95 citations

Two different thresholds of wingless signalling with distinct developmental consequences in the Drosophila midgut.

1995 • 91 citations

Universal β-galactosidase cloning vectors for promoter analysis and gene targeting

1994 • 36 citations

Nucleotide sequence and tissue distribution of mouse transforming growth factor-α

1992 • 31 citations