Unwrapping the genes of myelin

Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1

1984 • 723 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System

1964 • 607 citations

Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin

1985 • 538 citations

PROTEIN COMPOSITION OF MYELIN OF THE PERIPHERAL NERVOUS SYSTEM

1973 • 446 citations

Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture.

1980 • 444 citations

Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1

1983 • 431 citations

Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype

1987 • 389 citations

Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice

1983 • 382 citations

The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily

1987 • 370 citations

Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.

1979 • 360 citations

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein

1985 • 345 citations

A year in the life of the immunoglobulin superfamily

1987 • 345 citations

Gene expression in rat brain

1983 • 344 citations

Axons regulate Schwann cell expression of the major myelin and NGF receptor genes

1988 • 335 citations

Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte-oligodendrocyte interaction.

1987 • 335 citations

Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice

1985 • 331 citations

Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing.

1987 • 320 citations

Alternative splicing accounts for the four forms of myelin basic protein

1985 • 306 citations

Absence of the major dense line in myelin of the mutant mouse ‘shiverer’

1979 • 299 citations

Molecular cloning and primary structure of myelin-associated glycoprotein.

1987 • 284 citations

Proteins of Myelin

1977 • 281 citations

Two polyphosphatidylinositide metabolites control two K+ currents in a neuronal cell

1986 • 268 citations

ELECTRON MICROSCOPIC DEMONSTRATION OF CONNECTIONS BETWEEN GLIA AND MYELIN SHEATHS IN THE DEVELOPING MAMMALIAN CENTRAL NERVOUS SYSTEM

1962 • 245 citations

Neurological Mutations Affecting Myelination

1981 • 242 citations

Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons

1985 • 234 citations

Compact myelin exists in the absence of basic protein in the shiverer mutant mouse

1980 • 224 citations

Axonal regulation of myelin protein mRNA levels in actively myelinating Schwann cells

1988 • 224 citations

Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.

1986 • 219 citations

Immunocytochemical localization of basic protein in major dense line regions of central and peripheral myelin

1982 • 214 citations

Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders

1985 • 213 citations

Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin

1979 • 210 citations

The oligodendrocyte-type-2 astrocyte cell lineage is specialized for myelination

1986 • 201 citations

Schwann cells stimulated to proliferate in the absence of neurons retain full functional capability

1986 • 201 citations

Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin

1987 • 194 citations

Morphology of Myelin and Myelination

1984 • 189 citations

Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides

1983 • 188 citations

Shiverer: an autosomal recessive mutant mouse with myelin deficiency

1981 • 187 citations

Immunocytochemical localization of P0 protein in Golgi complex membranes and myelin of developing rat Schwann cells.

1981 • 184 citations

Individual exons encode the integral membrane domains of human myelin proteolipid protein.

1986 • 177 citations

Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.

1987 • 174 citations

Myelin-Associated Glycoprotein in Development and Disease

1983 • 172 citations

A Single Nucleotide Difference in the Gene for Myelin Proteolipid Protein Defines the Jimpy Mutation in Mouse

1987 • 167 citations

Animal Models of Genetic Disorders of Myelin

1984 • 159 citations

The timely expression of myelin basic protein gene in cultured rat brain oligodendrocytes is independent of continuous neuronal influences

1985 • 158 citations

The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice

1986 • 154 citations

Myelin‐specific proteolipid protein is expressed in myelinating schwann cells but is not incorporated into myelin sheaths

1987 • 154 citations

The early region of human papovavirus JC induces dysmyelination in transgenic mice

1986 • 149 citations

Molecular Structure, Localization, and Possible Functions of the Myelin‐Associated Enzyme 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase

1988 • 147 citations

Studies on cultured rat Schwann cells. III. Assays for peripheral myelin proteins

1980 • 144 citations

Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation.

1986 • 143 citations

Abnormal compact myelin in the myelin-deficient rat: absence of proteolipid protein correlates with a defect in the intraperiod line.

1987 • 142 citations

Schwann cell responses to cyclic AMP: Proliferation, change in shape, and appearance of surface galactocerebroside

1986 • 140 citations

Developmental regulation of myelin basic protein expression in mouse brain

1983 • 138 citations

Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.

1987 • 132 citations

Nerve growth factor receptors on cultured rat Schwann cells

1988 • 131 citations

Structure and molecular arrangement of proteolipid protein of central nervous system myelin.

1984 • 130 citations

Structure and expression of the mouse myelin proteolipid protein gene

1987 • 130 citations

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

1987 • 127 citations

The Primary Structure of Bovine Brain Myelin Lipophilin (Proteolipid Apoprotein)

1983 • 126 citations

Complete amino acid sequence of PO protein in bovine peripheral nerve myelin.

1987 • 122 citations

Predicted Folding of β‐Structure in Myelin Basic Protein

1984 • 111 citations

Defective biosynthesis of proteolipid protein in pelizaeus‐merzbacher disease

1987 • 105 citations

Brain proteolipids in neurological mutant mice

1973 • 82 citations

Studies on the control of myelinogenesis. IV. Neuronal induction of Schwann cell myelin-specific protein synthesis during nerve fiber regeneration

1982 • 80 citations

Nuclear factors in human brain cells bind specifically to the JCV regulatory region.

1988 • 80 citations

Physiological Basis of Conduction in Myelinated Nerve Fibers

1977 • 77 citations

Myelin proteolipid protein (PLP and DM-20) transcripts are deleted in jimpy mutant mice.

1986 • 71 citations

Amino acid sequence of bovine white matter proteolipid

1983 • 70 citations

Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice

1988 • 67 citations

Observations on the fine structure of peripheral nerve myelin

1969 • 57 citations

Perennial N2 supersaturation in an Antarctic lake

1987 • 56 citations

Shiverer gene maps near the distal end of chromosome 18 in the house mouse

1985 • 48 citations

Inefficient Transcription of the Myelin Basic Protein Gene Possibly Causes Hypomyelination in Myelin‐Deficient Mutant Mice

1987 • 48 citations

Changes in excitable membrane properties in Schwann cells of adult rabbit sciatic nerves following nerve transection.

1988 • 46 citations

A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts

1988 • 37 citations

Evidence for an ancestral immunoglobulin gene coding for half a domain

1975 • 36 citations

Myelin-associated glycoprotein and myelinating Schwann cell-axon interaction in chronic B,B'-iminodipropionitrile neuropathy.

1984 • 36 citations

Shiverer and Normal Peripheral Myelin Compared: Basic Protein Localization, Membrane Interactions, and Lipid Composition

1985 • 31 citations

Enzymic and chemical fragmentation of the apoprotein of the major rat brain myelin proteolipid

1983 • 28 citations

Lipophilin (Proteolipid Apoprotein) of Brain White Matter. Purification and Amino Acid Sequence Studies of the Four Tryptophan Fragments

1982 • 26 citations

A General Model of the P₂ Protein of Peripheral Nervous System Myelin Based on Secondary Structure Predictions, Tertiary Folding Principles, and Experimental Observations

1983 • 20 citations

Comparison of the Major Proteins of Shark Myelin with the Proteins of Higher Vertebrates

1984 • 20 citations

Hypomyelinated mutant mice IV: Peripheral myelin injpmsd

1981 • 11 citations

Bovine P2 Myelin Basic Protein Crystallizes in Three Different Forms

1988 • 8 citations