Limited heterogeneity of autoantigens and T cells in autoimmune diseases?

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus

1991 • 394 citations

A maternally inherited superantigen encoded by a mammary tumour virus

1991 • 335 citations

Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice

1991 • 307 citations

Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes

1991 • 297 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus

1991 • 277 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 • 190 citations

Immunogenetic and Biological Aspects of in Vitro Lymphocyte Allotransformation (MLR) in the Mouse

1973 • 159 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

The Role of Viruses and Environmental Factors in the Induction of Diabetes

1990 • 132 citations

The Role of Class II Molecules in Development of Insulin-Dependent Diabetes Mellitus in Mice, Rats and Humans

1990 • 18 citations