Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation

1997 • 2,216 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

1994 • 1,199 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

Identification and characterization of a novel monocyte subpopulation in human peripheral blood

1989 • 941 citations

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

Genetic influence on cytokine production and fatal meningococcal disease

1997 • 814 citations

Septic shock: pathogenesis

1991 • 743 citations

An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.

1993 • 682 citations

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

1990 • 643 citations

CD14: Cell surface receptor and differentiation marker

1993 • 600 citations

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF‐a and TNF‐0 by human mononuclear cells: a possible link to insulin‐dependent diabetes mellitus

1993 • 562 citations

Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum.

1986 • 549 citations

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1995 • 543 citations

Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation

1992 • 469 citations

Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

1995 • 459 citations

Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes.

1991 • 427 citations

Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation.

1995 • 279 citations

Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines.

1996 • 251 citations

Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs.

1992 • 212 citations

Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid

1997 • 198 citations

Tumor Necrosis Factor Promoter Polymorphism and Susceptibility to Lepromatous Leprosy

1997 • 195 citations

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

1991 • 186 citations

Interleukin 4 down‐regulates the expression of CD14 in normal human monocytes

1990 • 158 citations

Recombinant soluble CD14 inhibits LPS-induced tumor necrosis factor-alpha production by cells in whole blood.

1994 • 152 citations

Cerebrospinal Fluid Cachectin/Thmor Necrosis Factor- and Platelet-Activating Factor Concentrations and Severity of Bacterial Meningitis in Children

1990 • 141 citations

Endotoxin-neutralizing capacity of soluble CD14

1992 • 137 citations

Cytokine gene polymorphisms in inflammatory bowel disease.

1996 • 129 citations

Biochemistry and expression of myelomonocytic antigens.

1986 • 129 citations

Differential expression of cytokines in human blood monocyte subpopulations [see comments]

1992 • 110 citations

Polymorphism of tumour necrosis factor-alpha (TNF-α) at position −308 in relation to ankylosing spondylitis

1994 • 99 citations

Rapid HLA-DQB typing by eight polymerase chain reaction amplifications with sequence-specific primers (PCR-SSP)

1993 • 85 citations

Novel method for the measurement of cytokine production by a one-stage procedure

1993 • 62 citations

Induction of differentiation of human myeloid cell lines by tumor necrosis factor in cooperation with 1 alpha,25-dihydroxyvitamin D3.

1987 • 40 citations

Interleukin 12: A Proinflammatory Cytokine with Immunoregulatory Functions That Bridge Innate Resistance and Antisen-Specific Adaptive Immunity

1995 • 30 citations