Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2006 • 3,099 citations

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

2005 • 1,901 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

2001 • 1,153 citations

Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus

1995 • 1,135 citations

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

2000 • 1,119 citations

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 • 1,119 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Mechanism by which metformin reduces glucose production in type 2 diabetes.

2000 • 1,017 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

1998 • 798 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

2008 • 659 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

1998 • 508 citations

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

2006 • 449 citations

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

1999 • 442 citations

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

2003 • 410 citations

Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

2002 • 316 citations

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ

2006 • 267 citations

Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

2008 • 261 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 220 citations

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

2007 • 217 citations

The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

2006 • 216 citations

Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice

2005 • 175 citations

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

2003 • 173 citations

Modeling Error and Apparent Isotope Discrimination Confound Estimation of Endogenous Glucose Production During Euglycemic Glucose Clamps

1988 • 157 citations

Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN

2006 • 152 citations

Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit

2000 • 149 citations

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

2003 • 148 citations

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.

1994 • 140 citations

Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents

2003 • 138 citations

Therapeutic Potential of Phosphoinositide 3-Kinase Inhibitors

2003 • 126 citations

Atypical protein kinase C in insulin action and insulin resistance

2005 • 111 citations

Intrahepatic Mechanisms Underlying the Effect of Metformin in Decreasing Basal Glucose Production in Rats Fed a High-Fat Diet

2002 • 104 citations

Determinants Affecting Physical Activity Levels In Animal Models¹

2002 • 98 citations

Ablation of ARNT/HIF1β in Liver Alters Gluconeogenesis, Lipogenic Gene Expression, and Serum Ketones

2009 • 80 citations

Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver

2004 • 79 citations

High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice

2007 • 63 citations

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases

2000 • 59 citations

p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity

2000 • 59 citations

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

2009 • 51 citations

Mosaic analysis of insulin receptor function

2004 • 38 citations

Tissue-Specific Differences in Activation of Atypical Protein Kinase C and Protein Kinase B in Muscle, Liver, and Adipocytes of Insulin Receptor Substrate-1 Knockout Mice

2004 • 38 citations

Structure and function of phosphatidylinositol-3,4 kinase

2000 • 31 citations

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases

2000 • 13 citations