EPITHELIAL AND FIBROBLAST CELL LINES DERIVED FROM A SPONTANEOUS MAMMARY CARCINOMA IN A MMTV/neu TRANSGENIC MOUSE

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Annual Report to the Nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden

2002 • 896 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

1997 • 488 citations

Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine.

1999 • 339 citations

Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue.

1993 • 320 citations

Monoclonal antibody therapy of human cancer: Taking the HER2 protooncogene to the clinic

1991 • 296 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

1994 • 188 citations

Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein.

1996 • 185 citations

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

1997 • 178 citations

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

1993 • 173 citations

Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts.

1997 • 157 citations

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1995 • 147 citations

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

1994 • 144 citations

Idiotype vaccination against murine B cell lymphoma. Humoral and cellular requirements for the full expression of antitumor immunity.

1990 • 144 citations

Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency

1994 • 142 citations

High frequency of aberrant p16(INK4A) expression in human breast cancer.

1996 • 134 citations

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

1998 • 128 citations

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma

1994 • 116 citations

Protection against mammary tumor growth by vaccination with full-length, modified humanErbB-2 DNA

1999 • 110 citations

DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.

1998 • 107 citations

Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer.

1995 • 107 citations

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation.

1996 • 104 citations

Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes

1999 • 104 citations

Two distinct regions involved in 1p deletion in human primary breast cancer.

1993 • 101 citations

Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells.

1995 • 95 citations

Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.

1994 • 91 citations

Localization of Human Cadherin Genes to Chromosome Regions Exhibiting Cancer-Related Loss of Heterozygosity

1998 • 85 citations

Vaccination with the extracellular domain of p185 neu prevents mammary tumor development in neu transgenic mice

1999 • 84 citations

Transgenic mouse models of mammary tumorigenesis.

1993 • 83 citations

Genetic immunization against neu /erbB2 transgenic breast cancer

1998 • 78 citations

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene.

1995 • 78 citations

Loss of heterozygosity on chromosome arm 16q in breast cancer metastases

1997 • 76 citations

Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas

1996 • 72 citations

Allelic loss on chromosome 1p is associated with progression and lymph node metastasis of primary breast carcinoma.

1998 • 70 citations

Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors.

1994 • 58 citations

Allelic loss on chromosome 1p is Associated with progression and lymph node metastasis of primary breast carcinoma

1998 • 54 citations

Targeting HER-2/neu for active-specific immunotherapy in a mouse model of spontaneous breast cancer

1999 • 54 citations

Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively

1988 • 52 citations

Prognostic significance of three novel biologic factors in a clinical trial of adjuvant therapy for node-negative breast cancer

1995 • 49 citations

A tumor suppressor gene on chromosome 1p32-pter controls the amplification of MYC family genes in breast cancer.

1994 • 48 citations

Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue

1998 • 47 citations

The extracellular domain of HER2/neu is a potential immunogen for active specific immunotherapy of breast cancer.

1990 • 45 citations

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice.

1997 • 42 citations

The murine Tcl1 oncogene: embryonic and lymphoid cell expression

1997 • 41 citations

The Human Mammary-Derived Growth Inhibitor (MDGI) Gene: Genomic Structure and Mutation Analysis in Human Breast Tumors

1996 • 35 citations

Autoantibody to p185 erbB2/neu oncoprotein by vaccination with xenogenic DNA

1997 • 30 citations

Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice.

1996 • 29 citations

Establishment and characterization of a new mammary adenocarcinoma cell line derived from MMTV neu transgenic mice

1998 • 26 citations

Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.

1999 • 25 citations

Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes

1997 • 20 citations

The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195.

1995 • 14 citations

cDNA isolation, expression, and chromosomal localization of the mousePcph proto-oncogene

1999 • 12 citations