Molecular analysis of mutations in T-lymphocytes from experienced Soviet cosmonauts

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences

1992 • 1,338 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes.

1996 • 560 citations

Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment

1991 • 491 citations

Smoking and low antioxidant levels increase oxidative damage to sperm DNA

1996 • 480 citations

Automated DNA sequencing of the human HPRT locus

1990 • 357 citations

Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families

1990 • 328 citations

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

1983 • 299 citations

Statistical test for the comparison of samples from mutational spectra

1987 • 292 citations

Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA.

1989 • 286 citations

Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks

1992 • 271 citations

IN VIVO SOMATIC MUTATIONS IN HUMANS: MEASUREMENT AND ANALYSIS

1990 • 197 citations

Does physical activity induce DNA damage?

1994 • 177 citations

DNA Double-strand Break Repair Determines the RBE of α-particles

1988 • 172 citations

Adaptive response of human lymphocytes to low-level radiation from radioisotopes or X-rays

1989 • 153 citations

Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene

1992 • 150 citations

A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes

1988 • 142 citations

Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells

1989 • 138 citations

Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells

1988 • 124 citations

Ionizing radiation and genetic risks III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation

1991 • 103 citations

Use of the clonal assay for the measurement of frequencies of HPRT mutants in T-lymphocytes from five control populations

1991 • 99 citations

The Dose Rate Dependence of Oncogenic Transformation by Neutrons May Be Due to Variation of Response during the Cell Cycle

1986 • 96 citations

Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations

1993 • 81 citations

Mutational spectra in human B-cells

1992 • 81 citations

Splicing Mutants and Their Second-Site Suppressors at the Dihydrofolate Reductase Locus in Chinese Hamster Ovary Cells

1993 • 77 citations

Adaptive response of human lymphocytes for the repair of radon-induced chromosomal damage

1991 • 73 citations

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

1995 • 73 citations

Variation in Radiation Response of Mammalian Cells as a Function of Oxygen Tension

1973 • 72 citations

V(D)J recombinase-mediated deletion of the hprt gene in T-lymphocytes from adult humans

1992 • 70 citations

Mutations affecting RNA splicing in man are detected more frequently in somatic than in germ cells

1990 • 65 citations

Software for the analysis of mutations at the human hprt gene

1994 • 62 citations

Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells.

1993 • 56 citations

The Effect of Oxygen on Low-Dose Hypersensitivity and Increased Radioresistance in Chinese Hamster V79-379A Cells

1994 • 54 citations

Molecular analysis of mutations affecting hprt mRNA splicing in human T‐lymphocytes in vivo

1992 • 51 citations

Human CYP2A6 activation of 4-(methylnitrosamino)-l-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells

1994 • 50 citations

Molecular analysis of hprt mutants induced by 2-cyanoethylene oxide in human lymphoblastoid cells

1990 • 41 citations

CHO Cell Repair of Single-Strand and Double-Strand DNA Breaks Induced by γ — and α-Radiations

1975 • 39 citations

Dietary· supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice

1995 • 38 citations

Spectrum of spontaneous mutations in a cDNA of the human hprt gene integrated in chromosomal DNA

1989 • 36 citations

PCR Volume 1

1991 • 35 citations

Spectrum of spontaneous HPRT mutations in TK6 human lymphoblasts

1993 • 27 citations

Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

1990 • 26 citations

Identification of aprt gene mutations induced in repair-deficient and P450-expressing CHO cells by the food-related mutagen/carcinogen, PhIP

1995 • 25 citations

Biological low-dose radiation effects

1991 • 24 citations

Meeting Report (with Extended Abstracts)

1990 • 18 citations

Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations

1994 • 14 citations

Spectrum of spontaneous missense mutations causing cyclic AMP-resistance phenotypes in cultured S49 mouse lymphoma cells differs markedly from those of mutations induced by alkylating mutagens

1994 • 13 citations

Defective splicing induced by 4NQO in the hamster hprt gene

1994 • 12 citations

Similar mutant frequencies observed between pairs of monozygotic twins

1997 • 11 citations

Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of chinese hamster ovary cells

1995 • 11 citations

Spectrum of protein-induced mutagenesis of the Escherichia coli crp gene

1994 • 6 citations