A comparison of the anti‐inflammatory and anti‐nociceptive activity of nitroaspirin and aspirin

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CYCLOOXYGENASES 1 AND 2

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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Pharmacological analysis of cyclooxygenase-1 in inflammation

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1969 • 778 citations

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1996 • 671 citations

Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years

1997 • 569 citations

<scp>l</scp>‐N^G‐nitro arginine methyl ester exhibits antinociceptive activity in the mouse

1991 • 481 citations

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 • 478 citations

Standardization of the rat paw formalin test for the evaluation of analgesics

1991 • 359 citations

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model

1999 • 331 citations

Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation

1973 • 318 citations

Novel nonsterodial anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat

1994 • 293 citations

NO‐naproxen vs. naproxen: ulcerogenic, analgesic and anti‐inflammatory effects

1997 • 189 citations

Hyperalgesia and allodynia

1992 • 186 citations

Gastrointestinal safety of nitric oxide–derived aspirin is related to inhibition of ICE-like cysteine proteases in rats

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A diclofenac derivative without ulcerogenic properties

1994 • 167 citations

A comparison of the effects of <scp>L</scp>‐NAME, 7‐NI and <scp>L</scp>‐NIL on carrageenan‐induced hindpaw oedema and NOS activity

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Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating

1973 • 154 citations

NO-aspirins: a class of new anti-inflammatory and antithrombotic agents

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Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

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Evolution: The causes of mass extinctions

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Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats

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In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

1999 • 95 citations

Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.

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Antinociceptive Properties of Steroids Isolated fromPhyllanthus corcovadensisin Mice

1995 • 86 citations

Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils

1997 • 85 citations

Selective cyclooxygenase-2 inhibitors for the treatment of arthritis

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Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin.

1998 • 72 citations

Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia

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Pro- and antinociceptive actions of serotonin (5-HT)1A agonists and antagonists in rodents: relationship to algesiometric paradigm

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Pharmacological modulation of edema mediated by prostaglandin, serotonin and histamine

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The anti-inflammatory, analgesic and antipyretic activities of non-narcotic analgesic drug mixtures in rats.

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Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

1996 • 41 citations

Anti-inflammatory Effects of Etodolac: Comparison with Other Non-steroidal Anti-inflammatory Drugs.

1994 • 37 citations

Synergistic anti‐nociceptive effect of <scp>l</scp>‐N^G‐nitro arginine methyl ester (<scp>l</scp>‐NAME) and flurbiprofen in the mouse

1992 • 34 citations

Synthesis of 4-[5-(substituted aryl)-4,5-dihydro-1H-pyrazol-3-yl]-3-phenyl-sydnones as antiinflammatory, antiarthritic and analgesic agents

1995 • 27 citations

Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats

1996 • 26 citations

Involvement of Pain Associated Anxiety in the Development of Morphine Tolerance in Formalin Treated Mice

1994 • 24 citations

Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat

1992 • 15 citations

Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats

1996 • 14 citations