Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

1994 • 862 citations

New insights into the mode of action of anti-inflammatory drugs

1995 • 853 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.

1996 • 597 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

1996 • 474 citations

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

1994 • 462 citations

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1995 • 414 citations

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

1994 • 410 citations

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

1997 • 326 citations

Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

1995 • 312 citations

A model to evaluate mild analgesics in oral surgery outpatients

1976 • 305 citations

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1996 • 281 citations

Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro.

1992 • 260 citations

Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date

1996 • 248 citations

The correlation between blood levels of ibuprofen and clinical analgesic response

1986 • 235 citations

Cyclooxygenase‐2 Induction in Cerebral Cortex: An Intracellular Response to Synaptic Excitation

1996 • 201 citations

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

1994 • 178 citations

NSAID gastropathy: the second most deadly rheumatic disease? Epidemiology and risk appraisal.

1991 • 161 citations

Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms

1995 • 156 citations

Five Studies on Ibuprofen for Postsurgical Dental Pain

1984 • 137 citations

Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and ( S )-flurbiprofen following extraction of impacted third molars

1997 • 115 citations

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells

1996 • 106 citations

Ibuprofen and Acetaminophen in the Relief of Acute Pain: A Randomized, Double‐Blind, Placebo‐Controlled Study

1989 • 101 citations

Chapter 21. Selective Cyclooxygenase-2 Inhibitors

1997 • 100 citations

Multicenter Clinical Trial of Ibuprofen and Acetaminophen in the Treatment of Postoperative Dental Pain

1990 • 93 citations

Cyclooxygenase‐2 and its regulation in inflammation

1996 • 85 citations

Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization

1997 • 61 citations

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

1997 • 47 citations

A Placebo‐Controlled Comparative Evaluation of Diclofenac Dispersible Versus Ibuprofen in Postoperative Pain After Third Molar Surgery

1994 • 46 citations

Isoenzyme-specific cyclooxygenase inhibitors: A whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6

1997 • 44 citations

The efficacy of locally applied aspirin and acetaminophen in postoperative pain after third molar surgery

1992 • 33 citations