Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 • 653 citations

Simple Techniques for the Surgical Occlusion of Coronary Vessels in the Rat

1960 • 543 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

1993 • 529 citations

Plasma endothelin in chronic heart failure.

1992 • 494 citations

Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation.

1991 • 340 citations

Immunoreactive endothelin in human plasma: Marked elevations in patients in cardiogenic shock

1989 • 330 citations

Increased plasma endothelin-1 in the early hours of acute myocardial infarction

1991 • 298 citations

Presence of immunoreactive endothelin in human plasma

1989 • 258 citations

A New Method for Continuous Chronic Measurement and Recording of Blood Pressure, Heart Rate and Activity in the Rat Via Radio-telemetry

1991 • 251 citations

Elevated endothelin-1 in heart failure and loss of normal response to postural change.

1992 • 251 citations

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

1991 • 243 citations

Endothelial cells in culture produce a vasoconstrictor substance

1987 • 195 citations

Increased Plasma Concentrations of Endothelin in Congestive Heart Failure in Humans

1992 • 191 citations

Circulating immunoreactive endothelin in ischemic heart disease

1990 • 182 citations

Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation

1992 • 159 citations

Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome

1993 • 146 citations

Plasma big endothelin-1 concentrations in congestive heart failure patients with or without systemic hypertension

1993 • 127 citations

Plasma endothelin-1 levels in idiopathic dilated cardiomyopathy

1991 • 97 citations

Plasma endothelin-1 in acute myocardial infarction with heart failure

1993 • 89 citations

CYCLOSPORINE-INDUCED ELEVATION IN CIRCULATING ENDOTHELIN-1 IN PATIENTS WITH SOLID-ORGAN TRANSPLANTS

1993 • 87 citations

Biological Properties of the Angiotensin-Converting Enzyme Inhibitor Cilazapril

1985 • 72 citations

Ro 40–5967, in Contrast to Diltiazem, Does Not Reduce Left Ventricular Contractility in Rats with Chronic Myocardial Infarction

1991 • 65 citations

Plasma Endothelin-1 Levels in Stable and Unstable Angina

1993 • 56 citations

Influence of Congestive Heart Failure on Endothelin Levels and Receptors in Rabbits

1993 • 42 citations

Plasma immunoreactive endothelin in the acute and subacute phases of myocardial infarction in patients undergoing fibrinolysis

1993 • 41 citations

Radioimmunological Determination of Endothelin Peptides in Human Plasma: A Methodological Approach

1994 • 39 citations

Hemodynamic variability and circadian rhythm in rats with heart failure: role of locomotor activity

1993 • 38 citations

Endothelin-1 in patients with complicated and uncomplicated myocardial infarction

1992 • 35 citations

Free radical scavenging enzymes and G protein mediated receptor signalling systems in ischaemically preconditioned porcine myocardium

1993 • 24 citations

Plasma Concentrations of Endothelin-1 and Endothelin-3 Are Altered Differently in Various Pathophysiological Conditions

1991 • 23 citations

Increased plasma endothelin concentrations in patients with acute heart failure after myocardial infarction.

1993 • 22 citations

Plasma endothelin-1 concentrations in the coronary sinus in dogs with artificially induced myocardial infarction

1992 • 21 citations

Coronary Thrombolysis and Endothelin-1 Release

1993 • 15 citations

Identification of Cardiac Endothelin Binding Sites in Rats: Downregulation of Left Atrial Endothelin Binding Sites in Response to Myocardial Infarction

1991 • 7 citations

Renal glomerular endothelin receptors in rats with high-output heart failure

1991 • 7 citations