MPF Amplification inXenopusOocyte Extracts Depends on a Two-Step Activation of Cdc25 Phosphatase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Processing of Adenovirus 2-Induced Proteins

1973 • 762 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

1984 • 610 citations

Ordering S phase and M phase in the cell cycle

1994 • 596 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

Effects of cycloheximide on a cytoplasmic factor initiating meiotic maturation in Xenopus oocytes

1975 • 294 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

1993 • 291 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 inXenopusEgg Extracts

1998 • 214 citations

cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.

1992 • 211 citations

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

1989 • 179 citations

Induction of Xenopus Oocyte Meiotic Maturation by MAP Kinase

1995 • 154 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.

1995 • 144 citations

Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte: Antagonistic action of okadaic acid and 6-DMAP

1991 • 128 citations

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.

1993 • 120 citations

Activation of p34cdc2 kinase by cyclin A.

1991 • 111 citations

Inhibition of cdc2 activation by INH/PP2A.

1994 • 103 citations

Polo kinase: the choreographer of the mitotic stage?

1996 • 97 citations

Purification and characterization of a casein‐kinase‐II‐type enzyme from Xenopus laevis ovary

1988 • 73 citations

Levels of microtubules during the meiotic maturation of the Xenopus oocyte

1987 • 66 citations

Characterization of MPF activation by okadaic acid in Xenopus oocyte

1990 • 63 citations

Dependence of Mos-induced Cdc2 activation on MAP kinase function in a cell-free system.

1996 • 62 citations

Towards understanding the control of the division cycle in animal cells

1992 • 62 citations

Activation of p34cdc2 kinase by cyclin is negatively regulated by cyclic Amp-dependent protein kinase in Xenopus oocytes

1992 • 53 citations

Function and regulation of cdc25 protein phosphatase through mitosis and meiosis

1995 • 52 citations

Control of metaphase I formation in Xenopus oocyte: Effects of an indestructible cyclin B and of protein synthesis

1993 • 44 citations

Modulation of the substrate specificity of the polycation‐stimulated protein phosphatase from Xenopus laevis oocytes

1988 • 38 citations

Microinjection of Cdc25 protein phosphatase into Xenopus prophase oocyte activates MPF and arrests meiosis at metaphase I

1994 • 37 citations

The PR55 and PR65 Subunits of Protein Phosphatase 2A from Xenopus laevis. Molecular Cloning and Developmental Regulation of Expression

1995 • 36 citations

Activation of the Xenopus oocyte mitogen-activated protein kinase pathway by Mos is independent of Raf.

1996 • 34 citations

MAP Kinases in Meiosis

1998 • 33 citations

Regulation of cell divisions during oogenesis of vertebrates: The Xenopus oocyte paradigm

1993 • 32 citations

Identification of the ATP + Mg-dependent and polycation-stimulated protein phosphatases in the germinal vesicle of the Xenopus oocyte

1989 • 31 citations

Xenopus cyclin D2: Cloning and expression in oocytes and during early development

1996 • 14 citations