Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Processing of Adenovirus 2-Induced Proteins

1973 • 762 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

Oocyte Maturation

1979 • 662 citations

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

1988 • 617 citations

Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.

1984 • 575 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs

1994 • 471 citations

The cell cycle: an introduction

1994 • 466 citations

Parthenogenetic activation of oocytes in c-mos-deficient mice

1994 • 433 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Cdc2 regulatory factors

1994 • 414 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

The Product of the mos Proto-Oncogene as a Candidate "Initiator" for Oocyte Maturation

1989 • 333 citations

Cell cycle regulation of a Xenopus Wee1-like kinase.

1995 • 316 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

Effects of cycloheximide on a cytoplasmic factor initiating meiotic maturation in Xenopus oocytes

1975 • 294 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

1993 • 291 citations

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

1989 • 275 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes.

1992 • 271 citations

On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.

1991 • 262 citations

Maturation promoting factor, cyclin and the control of M-phase

1989 • 260 citations

Meiotic initiation by the mos protein in Xenopus

1992 • 253 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.

1992 • 236 citations

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

1995 • 232 citations

Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes.

1994 • 227 citations

Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.

1987 • 220 citations

Regulation of MPF activity in vitro

1988 • 209 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.

1992 • 191 citations

Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer

1993 • 184 citations

Two distinct mechanisms for negative regulation of the Wee1 protein kinase.

1993 • 178 citations

Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation.

1991 • 176 citations

Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.

1993 • 168 citations

Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.

1995 • 168 citations

Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.

1994 • 164 citations

Maturation and Fertilization in Starfish Oocytes

1984 • 163 citations

Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.

1992 • 163 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes.

1992 • 147 citations

Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.

1991 • 144 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.

1993 • 120 citations

Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.

1994 • 120 citations

Activation of p34cdc2 kinase by cyclin A.

1991 • 111 citations

Xenopus oocyte maturation does not require new cyclin synthesis.

1991 • 102 citations

Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.

1991 • 88 citations

Mos Stimulates MAP Kinase in Xenopus Oocytes and Activates a MAP Kinase Kinase In Vitro

1993 • 82 citations

Inhibition of mos-induced oocyte maturation by protein kinase A.

1993 • 81 citations

Cell Cycle Tyrosine Phosphorylation of p34^cdc2 and a Microtubule- Associated Protein Kinase Homolog in Xenopus Oocytes and Eggs

1991 • 79 citations

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

1993 • 76 citations

Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.

1992 • 75 citations

Molecular Mechanisms of the Activation of Maturation-Promoting Factor during Goldfish Oocyte Maturation

1995 • 75 citations

Tyrosine Phosphorylation and Activation of Homologous Protein Kinases during Oocyte Maturation and Mitogenic Activation of Fibroblasts

1991 • 61 citations

caenorhabditis elegans cyclin a- and b-type genes: A cyclin a multigene family, an ancestral cyclin b3 and differential germline expression

1995 • 59 citations

Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.

1994 • 55 citations

Activation of p34cdc2 kinase by cyclin is negatively regulated by cyclic Amp-dependent protein kinase in Xenopus oocytes

1992 • 53 citations

Protein synthesis is not involved in initiation or amplification of the maturation-promoting factor (MPF) in starfish oocytes

1982 • 50 citations

Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle.

1994 • 34 citations

Phosphorylation of Xenopus Cyclins B1 and B2 Is Not Required for Cell Cycle Transitions

1991 • 29 citations

Raf-1 Protein Kinase Is Important for Progesterone-Induced Xenopus Oocyte Maturation and Acts Downstream of mos

1993 • 22 citations

Reconstitution of p21ras-dependent and -independent mitogen-activated protein kinase activation in a cell-free system.

1993 • 21 citations

Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs

1994 • 10 citations

Activation of p34cdc2 kinase by cyclin is negatively regulated by cyclic amp-dependent protein kinase in Xenopus oocytes.

1992 • 2 citations