In Vitro Malignant Transformation — A Multi-Stepped Process

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

RNA tumor viruses

1982 • 833 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Evidence for the progressive nature of neoplastic transformation in vitro.

1978 • 313 citations

In Vitro Cell Transformation with Chemical Carcinogens

1963 • 304 citations

Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats

1966 • 285 citations

Carcinogenesis: Fundamental Mechanisms and Environmental Effects

1980 • 231 citations

Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis.

1983 • 209 citations

Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens

1978 • 204 citations

In Vitro Cell Transformation by X-Irradiation

1966 • 185 citations

Diethylstilbestrol Induces Neoplastic Transformation Without Measurable Gene Mutation at Two Loci

1981 • 185 citations

Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens

1982 • 174 citations

A SCANNING ELECTRON MICROSCOPE STUDY OF SURFACE FEATURES OF VIRAL AND SPONTANEOUS TRANSFORMANTS OF MOUSE BALB/3T3 CELLS

1973 • 167 citations

Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment

1978 • 164 citations

Structure and Function of the Transforming Genes of Human Adenoviruses and SV40

1980 • 108 citations

In Vitro Transformation of Normal Cells by Polyoma Virus

1961 • 106 citations

Frequency of UV-induced neoplastic transformation of diploid human fibroblasts is higher in xeroderma pigmentosum cells than in normal cells.

1982 • 101 citations

X-ray-induced in vitro Neoplastic transformation of human diploid cells

1980 • 101 citations

Comparison of Polyoma Virus Transcription in Productively Infected Mouse Cells and Transformed Rodent Cell Lines

1980 • 84 citations

Ultraviolet light-induced transformation of human cells to anchorage-independent growth.

1980 • 79 citations

Tumor induction by direct injection of cloned v-src DNA into chickens.

1983 • 70 citations

Induction of anchorage-independent growth in human fibroblasts by propane sultone.

1981 • 67 citations

Vasoformative sarcomas arising from BALB/3T3 cells attached to solid substrates.

1976 • 61 citations

Usage of vertebrate, invertebrate and plant cell, tissue and organ culture terminology

1984 • 57 citations

Mammalian cell transformation by chemical carcinogens

1980 • 51 citations

Multistep origin of tumor-forming ability in Chinese hamster embryo fibroblast cells.

1982 • 51 citations

Characterization of human cells transformed by chemical and physical carcinogens in vitro

1981 • 47 citations

Spontaneous, mutagen‐induced and adenovirus‐induced anchorage independent tumorigenic variants of mouse cells

1979 • 46 citations

Induction of Oncogenic Transformation by Low Doses of X Rays and Dose-Rate Effect

1984 • 40 citations

Characteristics of human diploid fibroblasts transformed in vitro by chemical carcinogens.

1983 • 40 citations

Emergence of hamster fibroblast tumors in nude mice—evidence for in vivo selection leading to loss of growth factor requirement

1981 • 39 citations

Action spectra for ultraviolet light-induced transformation of human cells to anchorage-independent growth.

1981 • 39 citations

Neoplasms induced with high single doses of N-ethyl-N-nitrosourea in 30-day-old Sprague-Dawley rats, with special emphasis on mammary neoplasia.

1984 • 34 citations

Clonal analysis of the stepwise appearance of anchorage independence and tumorigenicity in CAK, a permanent line of mouse cells.

1982 • 31 citations

Isolation of Human Diploid Cell Variants With Enhanced Colony-Forming Efficiency in Semisolid Medium After a Single-Step Chemical Mutagenesis: Brief Communication 2

1977 • 29 citations

Characterization of a quantitative assay for the in vitro transformation of normal human diploid fibroblasts to anchorage independence by chemical carcinogens.

1983 • 25 citations

Actin mutations in a human fibroblast model for carcinogenesis.

1982 • 24 citations

Morphologic Transformation and Chromosomal Changes Induced by Chemical Carcinogens in Skin Fibroblasts From Patients With Familial Adenomatosis Coli<xref ref-type="fn" rid="fn2">2</xref>

1982 • 24 citations

Transformation of tissue-cultured xeroderma pigmentosum fibroblasts by treatment with N-methyl-N′ -nitro-N-nitrosoguanidine

1976 • 18 citations

Starvation for arginine and glutamine sensitizes human diploid cells to the transforming effects of N-acetoxy-2-acetyl-aminofluorene

1981 • 18 citations

Presensitization of human cells with extrinsic signals to induced chemical carcinogenesis

1980 • 16 citations

Evidence that hamster fibroblast tumors emerge in nude mice through the process of two in vivo selections leading to growth factor “relaxation” and to immune resistance

1982 • 14 citations

Ultraviolet radiation-induced neoplastic transformation of normal human cells, in vitro

1981 • 12 citations

Characteristics of benzo[a]pyrene and A-ring reduced 7,12-dimethyl benz[a]anthracene induced neoplastic transformation of human cells in vitro

1981 • 11 citations

Transformation of Diploid Human Fibroblasts by Chemical Carcinogens

1980 • 9 citations

Morphological transformation in vitro of normal human fibroblasts by chrysotile.

1983 • 8 citations

Gamma-Rays from Proton Bombardment of Sodium

1955 • 7 citations

Transformation of fibroblasts from a patient with adenomatosis coli by treatment with a chemical carcinogen.

1980 • 4 citations