Detection of Early Changes in Autoimmune T Cell Phenotype and Function Following Intravenous Administration of Type II Collagen in a TCR-Transgenic Model

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Rapid colorimetric assay for cell growth and survival

1986 • 4,672 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice.

1997 • 465 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

Isolation and characterization of a chick cartilage collagen containing three identical chains

1971 • 395 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors.

1997 • 361 citations

Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis.

1982 • 339 citations

Two better cell lines for making hybridomas expressing specific T cell receptors.

1989 • 300 citations

Type ii collagen—induced arthritis in mice

1984 • 281 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

The Th1/Th2 paradigm and the allograft response

1996 • 262 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide.

1999 • 246 citations

Prevention and amelioration of collagen‐induced arthritis by blockade of the CD28 co‐stimulatory pathway: requirement for both B7‐1 and B7‐2

1996 • 244 citations

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

1998 • 225 citations

An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen

1997 • 222 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

IFN-γ Is Critical to the Control of Murine Autoimmune Encephalomyelitis and Regulates Both in the Periphery and in the Target Tissue: A Possible Role for Nitric Oxide

1999 • 204 citations

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis.

1996 • 203 citations

Intrathecal Delivery of IFN-γ Protects C57BL/6 Mice from Chronic-Progressive Experimental Autoimmune Encephalomyelitis by Increasing Apoptosis of Central Nervous System-Infiltrating Lymphocytes

2001 • 188 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.

1995 • 166 citations

Collagen‐Induced Arthritis

1996 • 157 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

The Role of CTLA-4 in Regulating Th2 Differentiation

1999 • 148 citations

Induction of Autoimmune Arthritis in HLA-DR4 (DRB1*0401) Transgenic Mice by Immunization with Human and Bovine Type II Collagen

1998 • 135 citations

Gene transfer of H-2 class II genes: Antigen presentation by mouse fibroblast and hamster B-cell lines

1984 • 135 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Antigen-specific therapy for autoimmune disease

2000 • 107 citations

Induction of tolerance to an IgG autoantibody.

1992 • 92 citations

T-cell activation and receptor downmodulation precede deletion induced by mucosally administered antigen

2000 • 82 citations

CD4 Regulation of TCR Signaling and T Cell Differentiation Following Stimulation with Peptides of Different Affinities for the TCR

1998 • 78 citations

Identification of MHC Class II and TCR Binding Residues in the Type II Collagen Immunodominant Determinant Mediating Collagen-Induced Arthritis

1996 • 68 citations

Treatment of Autoimmune Disease by Oral Tolerance to Autoantigens

1996 • 65 citations

Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.

1994 • 65 citations

Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns.

1992 • 62 citations

A CD4 cell is capable of transferring suppression of collagen-induced arthritis.

1989 • 57 citations

Transferable Anergy: Superantigen Treatment Induces CD4+ T Cell Tolerance That Is Reversible and Requires CD4−CD8− Cells and Interferon γ

1997 • 57 citations

Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis.

1995 • 38 citations

Characterization of the Adjuvant Effect of IL‐12 and Efficacy of IL‐12 Inhibitors in Type II Collagen‐Induced Arthritisa

1996 • 32 citations

IL-12 promotes cellular but not humoral type II collagen-specific T_h1-type responses in C57BL/6 and B10.Q mice and fails to induce arthritis

1996 • 25 citations

Differential Activities of Immunogenic Collagen Type II Peptides in the Induction of Nasal Tolerance to Collagen-Induced Arthritis

1999 • 20 citations

Properties of Antigen-Specific H-2 Restricted T Cell Hybridomas

1982 • 16 citations

Association of polymorphism at COL3A and CTLA4 loci on chromosome 2q31-33 with the clinical phenotype and in-vitro CMI status in healthy and leprosy subjects: a preliminary study

1997 • 15 citations

Oral tolerance in the control of experimental models of autoimmune disease.

1995 • 12 citations

Immune Deviation during the Induction of Tolerance by way of Nasal Installation.

1996 • 8 citations