Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

The Hallmarks of Cancer

2000 • 27,569 citations

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

Mechanisms of caspase activation

2003 • 1,358 citations

Intrinsic tumour suppression

2004 • 1,267 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

Pathways of apoptotic and non-apoptotic death in tumour cells

2004 • 1,026 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

1998 • 743 citations

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

2004 • 648 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

2001 • 546 citations

Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance

2002 • 437 citations

Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway

2003 • 368 citations

Pharmacological manipulation of cell death: clinical applications in sight?

2005 • 236 citations

Maintenance of caspase-3 proenzyme dormancy by an intrinsic “safety catch” regulatory tripeptide

2001 • 178 citations

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

1998 • 161 citations

Caspase 2 and Caspase 3 Protein Levels as Predictors of Survival in Acute Myelogenous Leukemia

1998 • 148 citations

Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL

2004 • 146 citations

Caspase 3 in breast cancer.

2003 • 139 citations

Direct activation of the apoptosis machinery as a mechanism to target cancer cells

2003 • 120 citations

High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.

1997 • 120 citations

Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion

1999 • 108 citations

Human Caspase-7 Activity and Regulation by Its N-terminal Peptide

2003 • 105 citations

Overexpression of caspase-3 in hepatocellular carcinomas

2004 • 104 citations

Characterization of the Interleukin-1β-Converting Enzyme/Ced-3-Family Protease, Caspase-3/CPP32, in Hodgkin's Disease

1999 • 82 citations

Targeting the FLICE Inhibitory Protein (FLIP) in Cancer Therapy

2003 • 68 citations

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

2004 • 65 citations

Role of Caspase 3-Dependent Bcl-2 Cleavage in Potentiation of Apoptosis by Bcl-2

2002 • 51 citations

Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines

1999 • 43 citations

Elevated procaspase levels in human melanoma

2001 • 41 citations

Mutations in the Procaspase-3 Dimer Interface Affect the Activity of the Zymogen

2003 • 40 citations

Direct Quantitation of Poly(ADP‐Ribose) Polymerase (PARP) Activity as a Means to Distinguish Necrotic and Apoptotic Death in Cell and Tissue Samples

2004 • 32 citations

Protein hijacking

2004 • 10 citations