Positive DNA supercoiling generates a chromatin conformation characteristic of highly active genes.

Supercoiling of the DNA template during transcription.

1987 • 1,909 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Assembly and propagation of repressed and derepressed chromosomal states

1985 • 518 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants

1988 • 277 citations

Supercoiling of intracellular DNA can occur in eukaryotic cells

1988 • 263 citations

Expression of transfected DNA depends on DNA topology

1986 • 246 citations

Chromatin fibers are left-handed double helices with diameter and mass per unit length that depend on linker length

1986 • 244 citations

Transcription on nucleosomal templates by RNA polymerase II in vitro: inhibition of elongation with enhancement of sequence-specific pausing.

1991 • 239 citations

Reversible changes in nucleosome structure and histone H3 accessibility in transcriptionally active and inactive states of rDNA chromatin

1983 • 231 citations

Eukaryotic RNA polymerase II binds to nucleosome cores from transcribed genes

1983 • 224 citations

Transcription of DNA injected into Xenopus oocytes is influenced by template topology

1983 • 219 citations

Site-specific recombination promotes plasmid amplification in yeast

1986 • 215 citations

A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it

1987 • 148 citations

Torsional stress promotes the DNAase I sensitivity of active genes

1984 • 145 citations

Transcription-induced nucleosome ‘splitting’: an underlying structure for DNase I sensitive chromatin.

1991 • 142 citations

Formation of nucleosomes on positively supercoiled DNA.

1991 • 133 citations

Chromatin fine structure of active and repressed genes

1981 • 114 citations

The yeast plasmid 2μ circle

1982 • 98 citations

Both DNA topoisomerases I and II relax 2 μm plasmid DNA in living yeast cells

1986 • 93 citations

The DNase I sensitive domain of the chicken Iysozyme gene spans 24 kb

1986 • 88 citations

Higher-order structure of Saccharomyces cerevisiae chromatin.

1989 • 75 citations

Structure of the chromatin axis during transcription

1988 • 72 citations

Yeast nudeosomes allow thermal untwisting of DNA

1987 • 68 citations

In vitro evidence that transcription-induced stress causes nucleosome dissolution and regeneration.

1990 • 54 citations

Transcription termination and chromatin structure of the active immunoglobulin kappa gene locus.

1986 • 54 citations

Signals for transcription initiation and termination in the Saccharomyces cerevisiae plasmid 2 micron circle.

1985 • 45 citations

Inhibition of transcription in eukaryotic cells by X-irradiation: relation to the loss of topological constraint in closed DNA loops

1988 • 44 citations

Template supercoiling during ATP-dependent DNA helix tracking: studies with simian virus 40 large tumor antigen.

1989 • 42 citations

Saccharomyces cerevisiae plasmid, Scp or 2 urn: intraceDular distribution, stability and nucleo-somal-like packaging

1980 • 36 citations

Location of DNAase I sensitive cleavage sites in the yeast 2 μm plasmid DNA chromosome

1984 • 26 citations

Signals for Transcription Initiation and Termination in the Saccharomyces cerevisiae Plasmid 2μm Circle

1985 • 20 citations