Colocalization Prostacyclin (PGI2) Synthase–Caveolin-1 in Endothelial Cells and New Roles for PGI2 in Angiogenesis

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

1999 • 1,315 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Caveolins, Liquid-Ordered Domains, and Signal Transduction

1999 • 1,016 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules.

1994 • 894 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

Endothelial Nitric Oxide Synthase Targeting to Caveolae

1996 • 670 citations

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1997 • 647 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

1977 • 625 citations

Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

1997 • 610 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta

1999 • 589 citations

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

2000 • 558 citations

Cholesterol Is Required for Surface Transport of Influenza Virus Hemagglutinin

1998 • 555 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

Caveolae and caveolins

1996 • 549 citations

Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

1996 • 532 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin

1998 • 506 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src

1999 • 481 citations

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

1990 • 452 citations

Molecular mechanisms of diverse actions of prostanoid receptors

1995 • 390 citations

Subcellular Localization of Prostaglandin Endoperoxide H Synthases-1 and -2 by Immunoelectron Microscopy

1998 • 338 citations

Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2

1999 • 295 citations

Tyrosine Nitration as a Mechanism of Selective Inactivation of Prostacyclin Synthase by Peroxynitrite

1997 • 287 citations

Cellular aspects of transcapillary exchange

1983 • 277 citations

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

1999 • 226 citations

VEGF Induces Nuclear Translocation of Flk-1/KDR, Endothelial Nitric Oxide Synthase, and Caveolin-1 in Vascular Endothelial Cells

1999 • 204 citations

Tyrosine Phosphorylation of Caveolin-1 in the Endothelium

1999 • 197 citations

Prostaglandin Biosynthesis and its Compartmentation in Vascular Smooth Muscle and Endothelial Cells

1986 • 195 citations

VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.

1994 • 166 citations

Synthesis of prostaglandin I2 (prostacyclin) by human and bovine endothelial cells

1977 • 164 citations

Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane.

1995 • 151 citations

Rate of Vasoconstrictor Prostanoids Released by Endothelial Cells Depends on Cyclooxygenase-2 Expression and Prostaglandin I Synthase Activity

1998 • 150 citations

A Role for the Caveolin Scaffolding Domain in Mediating the Membrane Attachment of Caveolin-1

1999 • 147 citations

Isolation and characterization of a cell surface albumin-binding protein from vascular endothelial cells.

1996 • 142 citations

Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells.

1994 • 130 citations

Molecular Cloning and Expression of Human Prostacyclin Synthase

1994 • 111 citations

Bimodal distribution of the prostaglandin I2 synthase antigen in smooth muscle cells.

1983 • 99 citations

Colocalization of Prostacyclin Synthase with Prostaglandin H Synthase-1 (PGHS-1) but Not Phorbol Ester-induced PGHS-2 in Cultured Endothelial Cells

2000 • 89 citations

Knockdown of Caveolin-1 by Antisense Oligonucleotides Impairs Angiogenesis in Vitro and in Vivo

2000 • 87 citations

Role of endothelial and smooth muscle cells in the physiopathology and treatment management of pulmonary hypertension

1999 • 83 citations

Prostacyclin Synthase Gene Transfer Accelerates Reendothelialization and Inhibits Neointimal Formation in Rat Carotid Arteries After Balloon Injury

1999 • 78 citations

Human Prostacyclin Synthase Gene and Hypertension

1999 • 75 citations

Interleukin 1β decreases prostacyclin synthase activity in rat mesangial cells via endogenous peroxynitrite formation

1998 • 63 citations

Prostacyclin (PGI2) Synthase Is a Constitutively Expressed Enzyme in Human Endothelial Cells

1995 • 49 citations

Caveolin Internalization by Heat Shock or Hyperosmotic Shock

2000 • 47 citations

Caveolae: Uniform Structures with Multiple Functions in Signaling, Cell Growth, and Cancer

2000 • 43 citations

Biosynthesis of prostacyclin in rat liver endothelial cells and its control by prostaglandin E2

1978 • 42 citations

Prostacyclin Synthase Active Sites

1997 • 37 citations

Molecular Cloning and Characterization of Bovine Prostacyclin Synthase

1994 • 35 citations

Pulmonary Hypertension -- Beyond Vasodilator Therapy

1998 • 23 citations

Prostacyclin synthase is localized in rat, bovine and human neuronal brain cells

1999 • 23 citations

Multiple fluorescence and reflectance simultaneous detection by confocal microscopy of HaeIII digested DNA sequences.

1996 • 9 citations

Post-transcriptional Regulation of Thromboxane A2 Synthase in U937 Cells

1995 • 3 citations