Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes

[4] Isolation and use of liver cells

1978 • 1,230 citations

Status of the mitochondrial pool of glutathione in the isolated hepatocyte.

1982 • 440 citations

Glutathione monoethyl ester: Preparation, uptake by tissues, and conversion to glutathione

1985 • 349 citations

The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver.

1982 • 336 citations

Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

1986 • 235 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

1981 • 220 citations

Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.

1986 • 200 citations

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

1978 • 188 citations

Conjugation Reactions In Drug Metabolism

1990 • 181 citations

Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo

1991 • 121 citations

Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities

1991 • 108 citations

Inhibition of human glutathione reductase by the nitrosourea drugs 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea and 1‐(2‐chloroethyl)‐3‐(2‐hydroxyethyl)‐1‐nitrosourea

1988 • 74 citations

Biochemistry of protein-isocyanate interactions: a comparison of the effects of aryl vs. alkyl isocyanates.

1987 • 68 citations

Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate

1991 • 64 citations

The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the rat

1981 • 61 citations

S-(N-Methylcarbamoyl)glutathione: A reactive S-linked metabolite of methyl isocyanate

1990 • 61 citations

Involvement of glutathione in 1-naphthylisothiocyanate (ANIT) metabolism and toxicity to isolated hepatocytes

1991 • 61 citations

Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro

1993 • 44 citations

Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.

1992 • 39 citations

Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.

1987 • 38 citations

Intestinal uptake and transmembrane transport systems of intact GSH; characteristics and possible biological role

1992 • 38 citations

S-(N-methylcarbamoyl)-N-acetylcysteine: A urinary metabolite of the hepatotoxic experimental antitumour agent N-methylformamide (NSC 3051) in mouse, rat and man

1986 • 36 citations

Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

1994 • 34 citations

Reversibility in Glutathione-Conjugate Formation

1994 • 33 citations

Chemical synthesis and cytotoxic properties of N-alkylcarbamic acid thioesters, metabolites of hepatotoxic formamides

1990 • 22 citations

Reduction of glutathione levels in livers of mice treated with N,N?-bis (2-chloroethyl)-N-nitrosourea

1979 • 21 citations

Inhibition of glutathione reductase activity by a carbomoylating nitrosourea: Effect on cellular radiosensitivity

1992 • 18 citations

Mechanism of glutathione-mediated DNA damage by the antineoplastic agent 1,3-bis(2-chloroethyl)-N-nitrosourea

1992 • 17 citations

Hepatotoxicity of N-methylformamide in mice—I

1987 • 17 citations

Studies on the metabolic fate of caracemide, an experimental antitumor agent, in the rat. Evidence for the release of methyl isocyanate in vivo

1993 • 17 citations

Toxicity of the methyl isocyanate metabolite S‐(N‐methylcarbamoyl)GSH on mouse embryos in culture

1992 • 15 citations

Formation and reversibility of S-linked conjugates of N-(1-methyl-3,3-diphenylpropyl)isocyanate, an in vivo metabolite of N-(1-methyl-3,3-diphenylpropyl)formamaide, in rats.

1990 • 13 citations

Oncolytic activity and mechanism of action of a novell-cystine derivative,l-cystine, ethyl ester,S-(N-methylcarbamate) monohydrochloride

1990 • 12 citations

Identification of carbamoylated thiol conjugates as metabolites of the antineoplastic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, in rats and humans.

1993 • 10 citations

Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent

1993 • 9 citations

Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments.

1978 • 5 citations