RNA processing errors in patients with beta-thalassemia.

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

The use of thin acrylamide gels for DNA sequencing

1978 • 1,449 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

1982 • 937 citations

Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro.

1977 • 711 citations

beta 0 thalassemia, a nonsense mutation in man.

1979 • 291 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

1981 • 236 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

Hematology of Infancy and Childhood

1981 • 206 citations

Recent developments in the molecular genetics of human hemoglobin

1979 • 199 citations

beta zero thalassemia in Sardinia is caused by a nonsense mutation.

1981 • 192 citations

Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes.

1981 • 129 citations

An intron nucleotide sequence variant in a cloned β⁺-thalassaemia globin gene

1981 • 124 citations

A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia.

1981 • 105 citations

Beta thalassemia: Mutations which affect processing of the β-globin mRNA precursor

1980 • 101 citations

Abnormally spliced messenger RNA in erythroid cells from patients with β+ thalassemia and monkey cells expressing a cloned β+-thalassemic gene

1982 • 91 citations

Structure and expression of a cloned β°thalassaemic globin gene

1981 • 85 citations

Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia.

1980 • 66 citations

Hemoglobin Messenger RNA from Human Bone Marrow ISOLATION AND TRANSLATION IN HOMOZYGOUS AND HETEROZYGOUS β-THALASSEMIA

1973 • 60 citations

Disorders of Human Hemoglobin

1980 • 59 citations

A mouse globin gene promoter is functional in SV40

1980 • 48 citations

Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia.

1977 • 43 citations

Two cloned β thalassemia genes are associated with amber mutations at codon 39

1981 • 33 citations

A new nonsense mutation as the molecular basis for β° thalassaemia

1982 • 25 citations

Simple rapid method for the synthesis of radioactively labeled cDNA hybridization probes utilizing bacteriophage M13mp7.

1982 • 24 citations

Posttranscriptional defects in beta-globin messenger RNA metabolism in beta-thalassemia: abnormal accumulation of beta-messenger RNA precursor sequences.

1981 • 15 citations