Receptor and Antibody Epitopes in Human Growth Hormone Identified by Homolog-Scanning Mutagenesis

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Tertiary templates for proteins

1987 • 1,485 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Use of Helical Wheels to Represent the Structures of Proteins and to Identify Segments with Helical Potential

1967 • 1,178 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

Continuous and discontinuous protein antigenic determinants

1986 • 582 citations

Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family

1988 • 564 citations

Three-dimensional structure of a genetically engineered variant of porcine growth hormone.

1987 • 457 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

A Specific Growth Hormone-Binding Protein in Human Plasma: Initial Characterization*

1986 • 424 citations

Structural Features of Prolactins and Growth Hormones That Can Be Related to Their Biological Properties*

1986 • 350 citations

Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences

1988 • 326 citations

Identification and characterization of specific binding proteins for growth hormone in normal human sera.

1986 • 313 citations

Human Growth Hormone

1988 • 304 citations

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4

1988 • 277 citations

Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites

1985 • 270 citations

Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein

1987 • 253 citations

A Newly Defined Property of Somatotropin: Priming of Macrophages for Production of Superoxide Anion

1988 • 208 citations

Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them.

1981 • 190 citations

Rabbit liver growth hormone receptor and serum binding protein. Purification, characterization, and sequence.

1988 • 190 citations

GENETIC ANALYSIS OF STAPHYLOCOCCAL NUCLEASE: IDENTIFICATION OF THREE INTRAGENIC "GLOBAL" SUPPRESSORS OF NUCLEASE-MINUS MUTATIONS

1985 • 189 citations

Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding

1988 • 175 citations

High-level secretion of human growth hormone by Escherichia coli

1987 • 150 citations

Antiviral activities of hybrids of two major human leukocyte interferons

1981 • 148 citations

Bacteriophage lambda cro mutations: effects on activity and intracellular degradation.

1986 • 145 citations

Importance of hydrogen-bond formation in stabilizing the transition state of subtilisin

1986 • 136 citations

Purified human growth hormone from E. coli is biologically active

1981 • 136 citations

Variants of Growth Hormone and Prolactin and their Posttranslational Modifications

1984 • 126 citations

Structural Variants of Human Growth Hormone: Biochemical, Genetic, and Clinical Aspects

1983 • 120 citations

Antigen-antibody interactions at the molecular level: adventures in peptide synthesis

1985 • 99 citations

Epitope mapping of the human immunodeficiency virus type 1 gp120 with monoclonal antibodies

1988 • 83 citations

Structural genes encoding the thermophilic alpha-amylases of Bacillus stearothermophilus and Bacillus licheniformis

1986 • 76 citations

Growth hormone, 1988.

1988 • 62 citations

Structure-function relationships for the interleukin 2 receptor: location of ligand and antibody binding sites on the Tac receptor chain by mutational analysis.

1988 • 58 citations

Monoclonal antibodies as probes of conformational changes in protein-engineered cytochrome c.

1988 • 55 citations

BINDING CHARACTERISTICS OF A BIOLOGICALLY ACTIVE VARIANT OF HUMAN GROWTH HORMONE (20K) TO GROWTH HORMONE AND LACTOGEN RECEPTORS

1981 • 48 citations

Fragments of Human Growth Hormone Produced by Digestion with Thrombin: Chemistry and Biological Properties*

1980 • 39 citations

Human growth hormone: 1974?1981

1991 • 39 citations

Receptor-binding and down-regulatory properties of 22000-Mr human growth hormone and its natural 20000-Mr variant on IM-9 human lymphocytes

1985 • 34 citations

Monoclonal antibodies to growth hormone and prolactin

1985 • 33 citations

Immunoreactivity and receptor binding of mixed recombinants of human growth hormone and chorionic somatomammotropin.

1978 • 29 citations

Antigenic sites of human growth hormone and related molecules detected by monoclonal antibodies to human growth hormone

1984 • 24 citations

Comparative Study of in Vitro and in Vivo Modulation of Lactogenic and Somatotropic Receptors by Native Human Growth Hormone and Its Modified Analog Prepared by Recombinant Deoxyribonucleic Acid Technology

1987 • 23 citations

Structure‐function studies on human growth hormone

1986 • 11 citations

Determination of the effect of acetylation of specific lysine residues in human growth hormone on its affinity for somatogenic receptors by an affinity selection technique

1988 • 6 citations

Preferred conformational state of the N‐terminus section of a bovine growth hormone fragment (residues 96‐133) in water is an omega loop

1988 • 3 citations