Down-regulation of Tumor Necrosis Factor Receptors by Blockade of Mitochondrial Respiration

Methods of Enzymatic Analysis

1975 • 20,446 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Methods of enzymatic analysis

1985 • 3,497 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

1988 • 1,288 citations

Molecular Biology of the Cell

1990 • 951 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

1986 • 585 citations

Peptide Regulatory Factors

1989 • 498 citations

Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.

1985 • 430 citations

Molecular biology of the cell (2nd edn)

1989 • 424 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1979 • 293 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

The molecular action of tumor necrosis factor-alpha

1991 • 279 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

1990 • 207 citations

Intracellular hydroxyl radical production induced by recombinant human tumor necrosis factor and its implication in the killing of tumor cells in vitro.

1989 • 199 citations

Polypeptide-Binding Membrane Receptors: Analysis and Classification

1981 • 195 citations

Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.

1987 • 181 citations

Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.

1984 • 180 citations

Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes

1992 • 169 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

1992 • 152 citations

Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor

1989 • 148 citations

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

1994 • 144 citations

Tumor Necrosis Factor Alpha Inhibits Hepatocyte Mitochondrial Respiration

1992 • 118 citations

Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor.

1992 • 117 citations

Superoxide generation by the respiratory chain of tumor mitochondria

1987 • 100 citations

Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha.

1987 • 84 citations

Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C.

1989 • 74 citations

Downregulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase C activators.

1987 • 73 citations

Use of monoclonal antibodies to a human cytotoxin for its isolation and for examining the self-induction of resistance to this protein.

1985 • 71 citations

Tumor necrosis factor: molecular and cellular biology and clinical relevance

1994 • 59 citations

Tumor necrosis factor receptors and cytocidal activity are down-regulated by activators of protein kinase C.

1988 • 58 citations

Prolactin receptors in cultured rat mammary tumor cells. Energy-dependent uptake and degradation of hormone receptors.

1982 • 50 citations

Tumor necrosis factor: Molecular and cellular biology and clinical relevance

1995 • 45 citations

Mechanism of human lymphotoxin and tumor necrosis factor induced destruction of cells in vitro: Phospholipase activation and deacylation of specific‐membrane phospholipids

1990 • 37 citations

Rapid modulation of tumor necrosis factor membrane receptors by activators of protein kinase C

1986 • 36 citations

Estadística en medicina

1986 • 34 citations

Regulation of the receptor for platelet-activating factor on human platelets

1993 • 18 citations

Differential effects of antimycin A on endocytosis and exocytosis of transferrin also are observed for internalization and externalization of beta-adrenergic receptors.

1993 • 14 citations

Relationship between intact cell ATP levels and glucocorticoid receptor-binding capacity in the AtT-20 cell

1985 • 9 citations