The role of copper transporters in the development of resistance to Pt drugs

Cisplatin: mode of cytotoxic action and molecular basis of resistance

2003 • 3,150 citations

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

1993 • 1,905 citations

Undetectable Intracellular Free Copper: The Requirement of a Copper Chaperone for Superoxide Dismutase

1999 • 1,573 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

1993 • 1,345 citations

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

2002 • 863 citations

The Copper Chaperone for Superoxide Dismutase

1997 • 828 citations

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

1993 • 720 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

Molecular mechanisms of copper uptake and distribution

2002 • 681 citations

Biochemical Characterization of the Human Copper Transporter Ctr1

2002 • 575 citations

h CTR1 : A human gene for copper uptake identified by complementation in yeast

1997 • 541 citations

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson Disease

1993 • 501 citations

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

1996 • 473 citations

CPx-type ATPases: a class of P-type ATPases that pump heavy metals

1996 • 472 citations

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

2001 • 435 citations

The copper transporter CTR1 provides an essential function in mammalian embryonic development

2001 • 368 citations

Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells

1990 • 357 citations

Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions

1994 • 355 citations

Cisplatin Binding Sites on Human Albumin

1998 • 344 citations

Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.

2000 • 327 citations

Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.

2002 • 287 citations

Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

2000 • 260 citations

A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.

1997 • 249 citations

The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae

2002 • 227 citations

Function and Regulation of the Mammalian Copper-transporting ATPases: Insights from Biochemical and Cell Biological Approaches

2003 • 206 citations

Identification of the Copper Regulon in Saccharomyces cerevisiae by DNA Microarrays

2000 • 189 citations

Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1)

2002 • 186 citations

Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.

2000 • 174 citations

Molecular Characterization of hCTR1, the Human Copper Uptake Protein

2002 • 174 citations

Enhanced transport of anticancer agents and leukotriene C₄ by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)

1999 • 157 citations

Isolation of a cDNA encoding the human homolog of COX17 , a yeast gene essential for mitochondrial copper recruitment

1997 • 153 citations

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network

1998 • 148 citations

Copper‐transporting P‐type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: Comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP

2002 • 140 citations

Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients.

2003 • 134 citations

Up-regulation of transporters of the MRP family by drugs and toxins

2001 • 126 citations

The Copper Export Pump ATP7B Modulates the Cellular Pharmacology of Carboplatin in Ovarian Carcinoma Cells

2003 • 121 citations

Role of the Na+, K(+)-adenosine triphosphatase in the accumulation of cis-diamminedichloroplatinum(II) in human ovarian carcinoma cells.

1991 • 88 citations

Mutation Analysis and Expression of the Mottled Gene in the Macular Mouse Model of Menkes Disease

1997 • 88 citations

Isolation of a Novel Human Canalicular Multispecific Organic Anion Transporter, cMOAT2/MRP3, and Its Expression in Cisplatin-Resistant Cancer Cells with Decreased ATP-Dependent Drug Transport

1998 • 87 citations

Interaction of cisplatin with methionine- and histidine-containing peptides: competition between backbone binding, macrochelation and peptide cleavage

2001 • 80 citations

Cross-resistance to cisplatin in cells with acquired resistance to copper

2004 • 69 citations

Characterization of the hCTR1 gene: Genomic organization, functional expression, and identification of a highly homologous processed gene

2000 • 67 citations

Intracellular localization of the Menkes and Wilson's disease proteins and their role in intracellular copper transport

1999 • 66 citations

Ascorbic acid increases drug accumulation and reverses vincristine resistance of human non-small-cell lung-cancer cells

1994 • 56 citations

Copper‐transporting P‐Type Adenosine Triphosphatase (ATP7B) Is Expressed in Human Breast Carcinoma

2002 • 55 citations

Potentiation of dna‐adduct formation and cytotoxicity of platinum‐containing drugs by low pH

1993 • 55 citations

Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line

2000 • 55 citations

Transport of cisplatin and bis-acetato-ammine-dichlorocyclohexylamine Platinum(IV) (JM216) in human ovarian carcinoma cell lines: identification of a plasma membrane protein associated with cisplatin resistance.

1995 • 53 citations

Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells.

1995 • 51 citations

Staffing in acute hospital wards: part 2. Relationships between grade mix, staff stability and features of ward organizational environment

2003 • 51 citations

Rupture of coronary aneurysm in Kawasaki disease

1999 • 42 citations

Antitumoral activity of a sulphur-containing platinum complex with an acidic pH optimum

2001 • 33 citations

Cross-resistance between cisplatin and antimony in a human ovarian carcinoma cell line.

1994 • 32 citations

Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line

2003 • 27 citations

Endosomal trafficking of the Menkes copper ATPase ATP7A is mediated by vesicles containing the Rab7 and Rab5 GTPase proteins

2003 • 26 citations

Copper Resistant Human Hepatoblastoma Mutant Cell Lines Without Metallothionein Induction Overexpress Atp7b

1998 • 23 citations

Amelioration of Cisplatin Toxicity in Rat Renal Cortical Slices by Dithiothreitol In vitro

1994 • 22 citations

Chemo-immunotherapeutical studies on Dalton's lymphoma in mice using cisplatin and ascorbic acid: synergistic antitumor effect in vivo and in vitro.

1993 • 22 citations

Expression of the Human Menkes ATPase in Xenopus laevis Oocytes

2001 • 8 citations

Heterologous Expression of the Metal‐Binding Domains of Human Copper‐Transporting ATPases (P₁‐ATPases)^a

1997 • 7 citations