Selective induction of growth factor production and growth factor receptor expression by different signals to a single t cell

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

1987 • 251 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61.

1985 • 203 citations

The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1.

1985 • 189 citations

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3.

1987 • 188 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.

1987 • 141 citations

Effective activation of resting mouse T lymphocytes by cross‐linking submitogenic concentrations of the T cell antigen receptor with either Lyt‐2 or L3T4

1987 • 120 citations

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

1986 • 106 citations

Autocrine growth of T cells independent of interleukin 2: identification of interleukin 4 (IL 4, BSF-1) as an autocrine growth factor for a cloned antigen-specific helper T cell.

1987 • 98 citations

Functions of Purified L3T4⁺ and Lyt‐2⁺ Cells in vitro and in vivo

1986 • 92 citations

Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.

1985 • 83 citations

Vβ gene polymorphism and a major polyclonal T cell receptor idiotype

1985 • 75 citations

Distinction between antigen receptor and IL 2 receptor triggering events in the activation of alloreactive T cell clones with calcium ionophore and phorbol ester.

1985 • 73 citations

Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody.

1987 • 60 citations

An antigen receptor-driven, interleukin 2-independent pathway for proliferation of murine cytolytic T lymphocyte clones.

1986 • 58 citations

Participation of L3T4 in T cell activation in the absence of class II major histocompatibility complex antigens. Inhibition by anti-L3T4 antibodies is a function both of epitope density and mode of presentation of anti-receptor antibody.

1987 • 36 citations

Direct interactions between B and T lymphocytes bearing complementary receptors.

1986 • 34 citations

Antigen-specific and -nonspecific mitogenic signals in the activation of human T cell clones.

1987 • 33 citations

T-cell receptor expressed on an autoreactive T-cell clone, clone 4

1985 • 28 citations

Different antigen-presenting cells differ in their capacity to induce lymphokine production and proliferation of an apo-cytochrome c-specific T cell clone.

1985 • 15 citations

Different effects of IL-2 addition or antibody crosslinking on T-cell subset stimulation by CD3 antibodies

1986 • 13 citations

Dissociation between the expression of IL 2 receptor and IL 2 receptor mRNA in the antigen-specific T cell clone stimulated by the specific antigen with B cell APC.

1987 • 12 citations