Tolerance induction in clinical transplantation

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Immunogenetic Consequences of Vascular Anastomoses Between Bovine Twins

1945 • 1,352 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

Strategies to Improve Long-Term Outcomes after Renal Transplantation

2002 • 836 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

2000 • 646 citations

Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen.

1989 • 636 citations

Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys

1995 • 552 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question

2001 • 519 citations

Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

2000 • 512 citations

RESULTS FROM A HUMAN RENAL ALLOGRAFT TOLERANCE TRIAL EVALUATING THE HUMANIZED CD52-SPECIFIC MONOCLONAL ANTIBODY ALEMTUZUMAB (CAMPATH-1H)

2003 • 432 citations

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

1999 • 418 citations

COMBINED HISTOCOMPATIBILITY LEUKOCYTE ANTIGENMATCHED DONOR BONE MARROW AND RENAL TRANSPLANTATION FOR MULTIPLE MYELOMA WITH END STAGE RENAL DISEASE: THE INDUCTION OF ALLOGRAFT TOLERANCE THROUGH MIXED LYMPHOHEMATOPOIETIC CHIMERISM

1999 • 418 citations

Mixed lymphohaemopoietic chimerism and graft-ver suslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation

1999 • 405 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

Mixed Chimerism and Transplant Tolerance

2001 • 391 citations

Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study

2003 • 379 citations

Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

1998 • 352 citations

Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.

1998 • 328 citations

CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

1999 • 306 citations

Kidney Transplantation Between Seven Pairs of Identical Twins

1958 • 299 citations

INDIRECT ALLORECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES IN HUMAN RENAL TRANSPLANT RECIPIENTS WITH CHRONIC GRAFT DYSFUNCTION1

1997 • 290 citations

LONG-TERM RESULTS OF A CONTROLLED PROSPECTIVE STUDY WITH TRANSFUSION OF DONOR-SPECIFIC BONE MARROW IN 57 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

1991 • 285 citations

Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane

2001 • 285 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Induction Of Kidney Allograft Tolerance After Transient Lymphohematopoietic Chimerism In Patients With Multiple Myeloma And End-Stage Renal Disease1

2002 • 269 citations

Intra–bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice

2001 • 268 citations

Survival of Donor Leukocyte Subpopulations in Immunocompetent Transfusion Recipients: Frequent Long-Term Microchimerism in Severe Trauma Patients

1999 • 267 citations

Immunologic Tolerance to Renal Allografts after Bone Marrow Transplants from the Same Donors

1991 • 266 citations

Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies

2000 • 259 citations

PROSPECTIVE EVALUATION OF PRETRANSPLANT BLOOD TRANSFUSIONS IN CADAVER KIDNEY RECIPIENTS

1997 • 255 citations

Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study

2000 • 245 citations

The complementary roles of deletion and regulation in transplantation tolerance

2003 • 238 citations

Pretransplantation Blood Transfusion Revisited

1991 • 220 citations

Heterologous immunity: an overlooked barrier to tolerance

2003 • 216 citations

FN18-CRM9 IMMUNOTOXIN PROMOTES TOLERANCE IN PRIMATE RENAL ALLOGRAFTS1

1997 • 212 citations

Mixed chimerism and immunosuppressive drug withdrawal after hla-mismatched kidney and hematopoietic progenitor transplantation1

2002 • 203 citations

Transplantation tolerance from a historical perspective

2001 • 198 citations

MODIFICATIONS OF THE CONDITIONING REGIMEN FOR ACHIEVING MIXED CHIMERISM AND DONOR-SPECIFIC TOLERANCE IN CYNOMOLGUS MONKEYS1

1997 • 187 citations

Acquired Immune Tolerance to Cadaveric Renal Allografts

1989 • 185 citations

Mixed Chimerism and Transplantation Tolerance

2001 • 184 citations

THYMIC DEPENDENCE OF LOSS OF TOLERANCE IN MIXED ALLOGENEIC BONE MARROW CHIMERAS AFTER DEPLETION OF DONOR ANTIGEN

1996 • 179 citations

Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen

1999 • 177 citations

LONG-TERM OUTCOME AND ALLOANTIBODY PRODUCTION IN A NON-MYELOABLATIVE REGIMEN FOR INDUCTION OF RENAL ALLOGRAFT TOLERANCE1

1999 • 167 citations

INTRATHYMIC DELETION OF ALLOREACTIVE T CELLS IN MIXED BONE MARROW CHIMERAS PREPARED WITH A NONMYELOABLATIVE CONDITIONING REGIMEN1

1998 • 166 citations

Anti-CD40 therapy extends renal allograft survival in rhesus macaques1

2002 • 158 citations

PERITRANSPLANT TOLERANCE INDUCTION IN MACAQUES: EARLY EVENTS REFLECTING THE UNIQUE SYNERGY BETWEEN IMMUNOTOXIN AND DEOXYSPERGUALIN1,2

1999 • 138 citations

HIGH-DOSE DONOR BONE MARROW INFUSIONS TO ENHANCE ALLOGRAFT SURVIVAL

1997 • 136 citations

INDUCTION THERAPY WITH MONOCLONAL ANTIBODIES SPECIFIC FOR CD80 AND CD86 DELAYS THE ONSET OF ACUTE RENAL ALLOGRAFT REJECTION IN NON-HUMAN PRIMATES1

2001 • 135 citations

PRECLINICAL STUDIES OF ALLOGRAFT TOLERANCE IN RHESUS MONKEYS

1997 • 129 citations

CLINICAL TRANSPLANTATION TOLERANCE TWELVE YEARS AFTER PROSPECTIVE WITHDRAWAL OF IMMUNOSUPPRESSIVE DRUGS: STUDIES OF CHIMERISM AND ANTI-DONOR REACTIVITY1

2000 • 128 citations

INDIRECT RECOGNITION OF DONOR HLA CLASS I PEPTIDES IN LUNG TRANSPLANT RECIPIENTS WITH BRONCHIOLITIS OBLITERANS SYNDROME1

1999 • 127 citations

ADDITIONAL MONOCLONAL ANTIBODY (mAB) INJECTIONS CAN REPLACE THYMIC IRRADIATION TO ALLOW INDUCTION OF MIXED CHIMERISM AND TOLERANCE IN MICE RECEIVING BONE MARROW TRANSPLANTATION AFTER CONDITIONING WITH ANTI-T CELL mABs AND 3-GY WHOLE BODY IRRADIATION1

1996 • 126 citations

Renal transplantation without immunosuppression in a host with tolerance induced by allogeneic bone marrow transplantation.

1994 • 125 citations

ANTI-CD154 OR CTLA4Ig OBVIATES THE NEED FOR THYMIC IRRADIATION IN A NON-MYELOABLATIVE CONDITIONING REGIMEN FOR THE INDUCTION OF MIXED HEMATOPOIETIC CHIMERISM AND TOLERANCE1

1999 • 120 citations

Evidence for thymic function in the elderly

2000 • 120 citations

Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies

2003 • 117 citations

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death

2001 • 117 citations

Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells

2004 • 110 citations

Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates1

2004 • 109 citations

Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1

2002 • 106 citations

TREATMENT WITH THE HUMANIZED CD154-SPECIFIC MONOCLONAL ANTIBODY, hu5C8, PREVENTS ACUTE REJECTION OF PRIMARY SKIN ALLOGRAFTS IN NONHUMAN PRIMATES1

2001 • 97 citations

Mixed Hematopoietic Chimerism Allows Cure of Autoimmune Diabetes Through Allogeneic Tolerance and Reversal of Autoimmunity

2004 • 96 citations

Renal transplantation for end‐stage renal disease following bone marrow transplantation: A report of six cases, with and without immunosuppression

1999 • 95 citations

Induction of specific unresponsiveness to heart allografts in mongrel dogs treated with total lymphoid irradiation and antithymocyte globulin.

1984 • 94 citations

Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential explanation for the blood-transfusion effect

2003 • 94 citations

PERIPHERAL BLOOD MICROCHIMERISM IN HUMAN LIVER AND RENAL TRANSPLANT RECIPIENTS

1997 • 91 citations

EVIDENCE THAT IMPROVED LATE RENAL TRANSPLANT OUTCOME CORRELATES WITH THE DEVELOPMENT OF IN VITRO DONOR ANTIGEN-SPECIFIC HYPOREACTIVITY

1993 • 88 citations

Indirect Allorecognition of Mismatched Donor HLA Class II Peptides in Lung Transplant Recipients with Bronchiolitis Obliterans Syndrome

2001 • 83 citations

Bone marrow transplantation attenuates murine IgA nephropathy: Role of a stem cell disorder

1999 • 80 citations

DURABLE DONOR-SPECIFIC T AND B CELL TOLERANCE IN RHESUS MACAQUES INDUCED WITH PERITRANSPLANTATION ANTI-CD3 IMMUNOTOXIN AND DEOXYSPERGUALIN

2000 • 79 citations

PROLONGATION OF PRIMATE CARDIAC ALLOGRAFT SURVIVAL BY TREATMENT WITH ANTI-CD40 LIGAND (CD154) ANTIBODY1

1999 • 77 citations

Retraction: Peritransplant Tolerance Induction with Anti-CD3-Immunotoxin: A Matter of Proinflammatory Cytokine Control

2008 • 77 citations

Donor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: A review of efficacy and mechanisms

1995 • 75 citations

PERITRANSPLANT TOLERANCE INDUCTION WITH ANTI-CD3-IMMUNOTOXIN

1998 • 75 citations

Outcomes of Renal Transplantation Following Bone Marrow Transplantation

2003 • 70 citations

Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow

1995 • 66 citations

Durable Donor-Specific T and B Cell Tolerance in Rhesus Macaques Induced with Peritransplantation Anti-CD3 Immunotoxin and Deoxyspergualin: Absence of Chronic Allograft Nephropathy

2006 • 65 citations

Successful stem cell transplantation following orthotopic liver transplantation from the same haploidentical family donor in a girl with hemophagocytic lymphohistiocytosis

2000 • 64 citations

Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance

2001 • 63 citations

Earlier Low-Dose TBI or DST Overcomes CD8+ T-Cell-Mediated Alloresistance to Allogeneic Marrow in Recipients of Anti-CD40L

2003 • 63 citations

Simultaneous Administration of Adjuvant Donor Bone Marrow in Pancreas Transplant Recipients

1999 • 61 citations

Induction and Mechanism of Tolerance to Bovine Serum Albumin in Mice Given Total Lymphoid Irradiation (TLI)

1978 • 60 citations

Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation

2002 • 59 citations

TOLERANCE IN RENAL TRANSPLANTATION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION???6-YEAR FOLLOW-UP

2001 • 57 citations

SPLIT TOLERANCE INDUCED BY IMMUNOTOXIN IN A RHESUS KIDNEY ALLOGRAFT MODEL1

1997 • 53 citations

ANALYSIS OF PRIMATE RENAL ALLOGRAFTS AFTER T-CELL DEPLETION WITH ANTI-CD3-CRM91,2

1998 • 53 citations

Tolerization of Galα1,3Gal‐reactive B cells in pre‐sensitized α1,3‐galactosyltransferase‐deficient mice by nonmyeloablative induction of mixed chimerism

2001 • 52 citations

Living donor liver transplantation and tolerance: a potential strategy in cholangiocarcinoma.

2003 • 51 citations

SELECTIVE DELETION OF ANTIGEN-SPECIFIC, ACTIVATED T CELLS BY A HUMANIZED MAB TO CD2 (MEDI-507) IS MEDIATED BY NK CELLS

1999 • 49 citations

TRANSPLANTATION TOLERANCE IN PRIMATES FOLLOWING TOTAL LYMPHOID IRRADIATION AND ALLOGENEIC BONE MARROW INJECTION I. ORTHOTOPIC LIVER ALLOGRAFTS

1980 • 45 citations

Approaches to transplantation tolerance in humans

2004 • 44 citations

Tolerance and near‐tolerance strategies in monkeys and their application to human renal transplantation

2001 • 43 citations

Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: The importance of overcoming intrathymic alloresistance

2001 • 42 citations

Infusion of donor leukocytes to induce tolerance in organ allograft recipients

1999 • 42 citations

Tolerance and chronic rejection

2001 • 38 citations

Cellular basis of long-term organ transplant acceptance: Pivotal role of intrathymic clonal deletion and thymic dependence of bone marrow microchimerism-associated tolerance

1998 • 38 citations

EVIDENCE FOR THE PRESENCE OF MULTILINEAGE CHIMERISM AND PROGENITORS OF DONOR DENDRITIC CELLS IN THE PERIPHERAL BLOOD OF BONE MARROW-AUGMENTED ORGAN TRANSPLANT RECIPIENTS1

1997 • 34 citations

Improved long-term graft outcome in lung transplant recipients who have donor antigen-specific hyporeactivity.

1994 • 33 citations

THIS ARTICLE HAS BEEN RETRACTED STEALTH matters: a novel paradigm of durable primate allograft tolerance

2001 • 32 citations

Retraction

2008 • 31 citations

Lack of Role for CsA‐Sensitive or Fas Pathways in the Tolerization of CD4 T Cells Via BMT and Anti‐CD40L

2003 • 31 citations

TRANSPLANTATION OF AUTOLOGOUS AND ALLOGENEIC BONE MARROW WITH LIVER FROM A CADAVERIC DONOR FOR PRIMARY LIVER CANCER1

2000 • 31 citations

The Abrogation of Allosensitization Following the Induction of Mixed Allogeneic Chimerism

2000 • 30 citations

TRANSPLANTATION TOLERANCE IN PRIMATES FOLLOWING TOTAL LYMPHOID IRRADIATION AND ALLOGENEIC BONE MARROW INJECTION II. RENAL ALLOGRAFTS

1980 • 30 citations

Mixed chimerism and transplantation tolerance induced by a nonlethal preparative regimen in cynomolgus monkeys

1997 • 29 citations

Combined Immunosuppressive Action of Phytohaemagglutinin and Azathioprine (Imuran) on Dogs with Renal Homotransplants

1965 • 28 citations

MECHANISMS OF TOLERANCE TO RAT HEART ALLOGRAFTS USING POSTTRANSPLANT TLI

1996 • 24 citations

Total lymphoid irradiation--current status.

1989 • 22 citations

EVALUATION OF PRE- AND POSTTRANSPLANT DONOR-SPECIFIC TRANSFUSION/CYCLOSPORINE A IN NON-HLA IDENTICAL LIVING DONOR KIDNEY TRANSPLANT RECIPIENTS

1999 • 22 citations

SELECTIVE LOSS OF FUNCTIONAL ANTIDONOR CYTOLYTIC T CELL PRECURSORS FOLLOWING DONOR-SPECIFIC BLOOD TRANSFUSIONS IN LONG- TERM RENAL ALLOGRAFT RECIPIENTS

1992 • 22 citations

Long-term kidney graft survival by delayed T cell ablative treatment in rhesus monkeys1,2

2002 • 19 citations

Megadose approach to DBMC infusion-induced allograft hyporesponsiveness in living-related renal allograft recipients

2001 • 16 citations

Blockade of CD40-CD154 at the time of donor-specific blood transfusion does not lead to prolonged kidney allograft survival in nonhuman primates1

2002 • 16 citations

Discontinuation of immunosuppression for prevention of kidney graft rejection after receiving a bone marrow transplant from the same HLA identical sibling donor

2002 • 12 citations

The future of organ transplantation: from the laboratory to the clinic

2001 • 12 citations

RETRACTED: Tolerance induced by anti-CD3 immunotoxin plus 15-deoxyspergualin associates with donor-specific indirect pathway unresponsiveness

2003 • 10 citations

TRANSPLANTATION TOLERANCE IN PRIMATES AFTER TOTAL LYMPHOID IRRADIATION AND ALLOGENEIC BONE MARROW INJECTION III. LYMPHOCYTE RESPONSIVENESS AND SUPPRESSOR CELL ACTIVITY

1980 • 9 citations

TOLERANCE IN BABOON KIDNEY TRANSPLANTATION WITH TOTAL LYMPHOID IRRADIATION (TLI) AND ANTI-CD3/CD4-IDARUBICIN CONJUGATES1

2001 • 7 citations