Angiotensin, LDL peroxidation and atherosclerosis

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Hypertension : pathophysiology, diagnosis, and management

1995 • 1,895 citations

Lewis A. Conner Memorial Lecture

1997 • 754 citations

Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.

1991 • 751 citations

Association of the Renin-Sodium Profile with the Risk of Myocardial Infarction in Patients with Hypertension

1991 • 734 citations

Circulating and tissue angiotensin systems.

1987 • 616 citations

Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.

1995 • 539 citations

Angiotensin-Converting Enzyme Inhibition Prevents Arterial Nuclear Factor-κB Activation, Monocyte Chemoattractant Protein-1 Expression, and Macrophage Infiltration in a Rabbit Model of Early Accelerated Atherosclerosis

1997 • 502 citations

Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease

1996 • 431 citations

The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence.

1991 • 429 citations

Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.

1990 • 419 citations

Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.

1993 • 409 citations

Modified forms of low density lipoprotein and atherosclerosis

1993 • 348 citations

Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV.

1995 • 303 citations

Angiotensin II Activates Programmed Myocyte Cell Deathin Vitro

1997 • 215 citations

Activation of human peripheral monocytes by angiotensin II

1994 • 210 citations

Effects of Captopril on Atherosclerosis in Cynomolgus Monkeys

1990 • 187 citations

Increased Plasma and Lipoprotein Lipid Peroxidation in apo E-Deficient Mice

1994 • 172 citations

Angiotensin II stimulates macrophage-mediated oxidation of low density lipoproteins

1995 • 151 citations

Chymase-dependent angiotensin II forming system in humans

1996 • 141 citations

The Angiotensin-II Receptor Antagonist, Losartan, Inhibits LDL Lipid Peroxidation and Atherosclerosis in Apolipoprotein E-Deficient Mice

1997 • 138 citations

Free radical generation, lipid peroxidation and essential fatty acids in uncontrolled essential hypertension

1990 • 137 citations

Low density lipoprotein isolated from patients with essential hypertension exhibits increased propensity for oxidation and enhanced uptake by macrophages: a possible role for angiotensin II

1994 • 106 citations

Inhibitors of angiotensin converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma cholesterol and captopril inhibits macrophage—foam cell accumulation independently of blood pressure and plasma lipids

1994 • 92 citations

Evidence That Angiotensin II Is Present in Human Monocytes

1995 • 86 citations

Angiotensin II–Modified LDL Is Taken Up by Macrophages Via the Scavenger Receptor, Leading to Cellular Cholesterol Accumulation

1996 • 78 citations

Role of oxygen-derived free radicals in acute angiotensin II--induced hypertensive vascular disease in the rat.

1990 • 76 citations

Renin Is Expressed in Rat Macrophage/Monocyte Cells

1996 • 71 citations

Immunolocalization of native antioxidant scavenger enzymes in early hypertensive and atherosclerotic arteries. Role of oxygen free radicals.

1992 • 70 citations

ACE inhibition with perindopril and atherogenesis-induced structural and functional changes in minipig arteries.

1993 • 57 citations

Bovine and human endothelial cell production of neutrophil chemoattractant activity in response to components of the angiotensin system.

1985 • 44 citations

Angiotensin II Injection into Mice Increases the Uptake of Oxidized LDL by Their Macrophages via a Proteoglycan-Mediated Pathway

1997 • 43 citations

Human Platelet Angiotensin II Receptors: Regulation by the Circulating Angiotensin Level*

1984 • 35 citations

Fosinopril Reduces ADP-Induced Platelet Aggregation in Hypertensive Patients

1996 • 35 citations

Effect of Angiotensin II on Collagen-Induced Platelet Activation in Normotensive Subjects

1990 • 26 citations

AUTORADIOGRAPHIC LOCALIZATION OF ANGIOTENSIN-CONVERTING ENZYME AND ANGIOTENSIN II BINDING SITES IN EARLY ATHEROMA-LIKE LESIONS IN RABBIT ARTERIES

1991 • 24 citations

Stimulation of rat vascular smooth muscle cell glycosaminoglycan production by angiotensin II

1994 • 18 citations

Aorta viscoelasticity and arterial histopathology of atherosclerotic pigs treated by angiotensin converting enzyme inhibition

1991 • 13 citations

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