Loss of Heterozygosity in Endometrial Carcinoma

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification

2002 • 2,637 citations

The impact of translocations and gene fusions on cancer causation

2007 • 1,319 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

The frequency of p53, k-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma

2000 • 453 citations

Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification

2004 • 356 citations

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

2001 • 320 citations

Molecular pathology of endometrial hyperplasia and carcinoma

2001 • 301 citations

MLPA and MAPH: New techniques for detection of gene deletions

2004 • 293 citations

Epigenetics provides a new generation of oncogenes and tumour-suppressor genes

2006 • 276 citations

Abnormalities of the APC/β-catenin pathway in endometrial cancer

2002 • 236 citations

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way

2004 • 213 citations

Progenetix.net: an online repository for molecular cytogenetic aberration data

2001 • 186 citations

Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers.

1995 • 181 citations

PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases

2000 • 169 citations

Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

2006 • 162 citations

Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas.

2003 • 146 citations

PIK3CA gene mutations in endometrial carcinoma. Correlation with PTEN and K-RAS alterations☆

2006 • 139 citations

Abnormalities of E‐ and P‐cadherin and catenin (β‐, γ‐catenin, and p120^ctn) expression in endometrial cancer and endometrial atypical hyperplasia

2003 • 133 citations

Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP.

2003 • 126 citations

Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the β-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis

2005 • 120 citations

K-ras mutations in endometrial carcinomas with microsatellite instability

2001 • 117 citations

Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence

2002 • 108 citations

Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.

1998 • 99 citations

A survey of homozygous deletions in human cancer genomes

2005 • 98 citations

A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta‐catenin in the desmoid tumor

2000 • 96 citations

Identification of a novel candidate gene,CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer

2004 • 90 citations

Allelotype of endometrial carcinoma.

1994 • 88 citations

Genomic aberrations in carcinomas of the uterine corpus

2004 • 70 citations

PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumour tissue

1993 • 68 citations

Distinct chromosomal imbalances in uterine serous and endometrioid carcinomas.

1998 • 67 citations

Genetic aberrations detected by comparative genomic hybridization predict outcome in patients with endometrioid carcinoma

2000 • 62 citations

Gene Conversion Is a Frequent Mechanism of Inactivation of the Wild-Type Allele in Cancers from MLH1/MSH2 Deletion Carriers

2006 • 62 citations

Mutation and allelic loss of the p53 gene in endometrial carcinoma. Incidence and outcome in 92 surgical patients

1995 • 57 citations

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN

2001 • 55 citations

Loss of heterozygosity in usual and special variant carcinomas of the endometrium

1997 • 50 citations

Mitotic Instability in Cancer: Is There Method in the Madness?

2005 • 49 citations

Genetic Imbalances in Precursor Lesions of Endometrial Cancer Detected by Comparative Genomic Hybridization

2000 • 45 citations

Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases

2004 • 45 citations

p16 INK4A Alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas

2003 • 43 citations

A modified mutagenic PCR-RFLP method for K-ras codon 12 and 13 mutations detection in NSCLC patients

2001 • 41 citations

The genetic origins of human cancer

1988 • 38 citations

DCC gene alteration in human endometrial carcinomas

1994 • 37 citations

Fluorescence in situ hybridization

2001 • 34 citations

Online database and bioinformatics toolbox to support data mining in cancer cytogenetics

2006 • 30 citations

Chromosomal alterations in 98 endometrioid adenocarcinomas analyzed with comparative genomic hybridization

2006 • 30 citations

Loss of heterozygosity analyzed by single nucleotide polymorphism array in cancer

2005 • 30 citations

Loss of heterozygosity of the retinoblastoma gene is correlated with the altered pRb expression in human endometrial cancer

2002 • 29 citations

Malignant Mixed Müllerian Tumor of the Uterus. Features Favoring its Origin from a Common Cell Clone and an Epithelial-to-Mesenchymal Transformation Mechanism of Histogenesis

1998 • 28 citations

Losses of Heterozygosity in Endometrial Adenocarcinomas

2000 • 25 citations

Frequent deletion of chromosome 1p sequences in an aggressive histologic subtype of endometrial cancer

1996 • 23 citations

fhit alterations in endometrial carcinoma and hyperplasia

2000 • 21 citations

Loss of heterozygosity of BRCA1, TP53 and TCRD markers analysed in sporadic endometrial cancer

1998 • 20 citations

Semiautomated quantitative detection of loss of heterozygosity in the tumor suppressor gene p53.

1995 • 19 citations

Genetic imbalances in endometrial hyperplasia and endometrioid carcinoma detected by comparative genomic hybridization

2005 • 17 citations

Allelic Loss of Chromosome 16q in Endometrial Cancer: Correlation with Poor Prognosis of Patients and Less Differentiated Histology

1996 • 17 citations

Allelic Loss at <i>TP53</i> Is Not Related to p53 Protein Overexpression in Primary Human Endometrial Carcinomas

2005 • 15 citations

A 1-Mb Bacterial Clone Contig Spanning the Endometrial Cancer Deletion Region at 1p32–p33

1999 • 12 citations

Loss of p16 in recurrent malignant mixed mullerian tumors of the uterus

2006 • 12 citations

13q deletions in B-cell lymphoproliferative disorders: frequent association with translocation

2007 • 11 citations

The evidence for human tumor suppressor genes.

1989 • 11 citations

LOSS OF POLYMORPHIC RESTRICTION FRAGMENTS OF CLASS I AND CLASS II MHC GENES IN A MALIGNANT MELANOMA

1986 • 9 citations

Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy

2002 • 9 citations

A model for genetic complementation controlling the chromosomal abnormalities and loss of heterozygosity formation in cancer

2007 • 7 citations

Identification of novel prognostic markers in cervical intraepithelial neoplasia using LDMAS (LOH Data Management and Analysis Software)

2005 • 7 citations

Epidermal growth factor receptor gene mutations in early pulmonary adenocarcinomas.

2007 • 5 citations

News reports

2002 • 2 citations