Fluorescence in situ hybridization

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Hematologic Remission and Cytogenetic Improvement Induced by Recombinant Human Interferon Alpha_Ain Chronic Myelogenous Leukemia

1986 • 675 citations

The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual Disease

1998 • 457 citations

Prolonged Survival in Chronic Myelogenous Leukemia after Cytogenetic Response to Interferon-α Therapy

1995 • 446 citations

Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia

1991 • 398 citations

Detection of bcr - abl Fusion in Chronic Myelogeneous Leukemia by in Situ Hybridization

1990 • 371 citations

Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia

1983 • 337 citations

Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients

1995 • 310 citations

Molecular evaluation of residual disease as a predictor of relapse in acute promyelocytic leukaemia

1992 • 241 citations

Acute promyelocytic leukemia

1986 • 224 citations

Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital

1989 • 197 citations

Highly Sensitive Fluorescence In Situ Hybridization Method to Detect Double BCR/ABL Fusion and Monitor Response to Therapy in Chronic Myeloid Leukemia

1998 • 189 citations

Disappearance of pH¹-Positive Cells in Four Patients with Chronic Granulocytic Leukemia after Chemotherapy, Irradiation and Marrow Transplantation from an Identical Twin

1979 • 161 citations

Prognostic significance of Philadelphia chromosome-positive cells detected by the polymerase chain reaction after allogeneic bone marrow transplant for chronic myelogenous leukemia

1992 • 145 citations

Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization

1994 • 144 citations

Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.

1997 • 128 citations

The application of fluorescent in situ hybridization to detect Mbcr/abl fusion in variant Ph chromosomes in CML and ALL

1993 • 118 citations

Translocation of BCR to chromosome 9: A new cytogenetic variant detected by FISH in two Ph‐negative, BCR‐positive patients with chronic myeloid leukemia

1993 • 99 citations

Should Polymerase Chain Reaction Analysis to Detect Minimal Residual Disease in Patients With Chronic Myelogenous Leukemia Be Used in Clinical Decision Making?

1999 • 92 citations

Phase II trial of pentostatin in refractory lymphomas and cutaneous T-cell disease.

1991 • 90 citations

Hypermetaphase fluorescence in situ hybridization for quantitative monitoring of Philadelphia chromosome-positive cells in patients with chronic myelogenous leukemia during treatment

1995 • 87 citations

Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization

1994 • 61 citations

Combined cytogenetic, FISH and molecular analysis in acute promyelocytic leukaemia at diagnosis and in complete remission

1995 • 47 citations

Interferon-α therapy for chronic myelogenous leukemia

1995 • 46 citations

Frequent detection of BCR-ABL specific mRNA in patients with chronic myeloid leukemia (CML) following allogeneic and syngeneic bone marrow transplantation (BMT).

1993 • 31 citations

Application of fluorescence in situ hybridization to detect residual leukemic cells with 9;22 and 15;17 translocations

1997 • 29 citations

Cell lineage specific involvement in acute promyelocytic leukaemia (APL) using a combination of May‐Grünwald‐Giemsa staining and fluorescence in situ hybridization techniques for the detection of the translocation t(15;17)(q22;q12)

1998 • 28 citations

Duplication of chromosome 9 carrying a BCR/ABL chimeric gene in Philadelphia chromosome negative chronic myeloid leukemia

1996 • 27 citations

Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia

1993 • 26 citations

FISH detection of mixed chimerism in 33 patients submitted to bone marrow transplantation.

1996 • 25 citations

Detection of the Mbcr/abl translocation in chronic myeloid leukemia by fluorescence in situ hybridization: Comparison with conventional cytogenetics and implications for minimal residual disease detection

1997 • 25 citations

Usefulness of detection of minimal residual disease by ‘hypermetaphase’ fluorescent in situ hybridization after allogeneic BMT for chronic myelogenous leukemia

1997 • 25 citations

Detection of residual leukemic cells in patients with acute promyelocytic leukemia by the fluorescence in situ hybridization method: potential for predicting relapse

1995 • 23 citations

Acute promyelocytic leukemia: All-trans retinoic acid (ATRA) along with chemotherapy is superior to ATRA alone

1999 • 22 citations

Detection of minimal residual disease after sex-mismatch bone marrow transplantation in chronic myelogenous leukemia by fluorescence in situ hybridization

1994 • 18 citations

Cytogenetic analysis is non-informative for assessing the remission rate in chronic myeloid leukemia (CML) patients on interferon-α (IFN-α) therapy

1995 • 18 citations

Value of Fluorescence In Situ Hybridization for Detecting the bcr/abl Gene Fusion in Interphase Cells of Routine Bone Marrow Specimens

1997 • 17 citations

Trilateral Retinoblastoma with an RB1 Deletion Inherited from a Carrier Mother

1999 • 11 citations

Detection of the Philadelphia chromosome in paraffin-embedded tissue by fluorescence in situ hybridization.

1994 • 11 citations

The polymerase chain reaction

1991 • 8 citations

High incidence of a second BCR-ABL fusion in chronic myeloid leukemia revealed by interphase cytogenetic analysis on blood and bone marrow smears

1996 • 8 citations

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