Adult precursor B-ALL with BCR/ABL gene rearrangements displays a unique immunophenotype based on the pattern of CD10, CD34, CD13 and CD38 expression

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).

1995 • 1,374 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease

1999 • 1,170 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

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The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

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1995 • 543 citations

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1995 • 452 citations

Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development

1987 • 451 citations

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

1987 • 448 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 354 citations

Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia

1998 • 313 citations

Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

1986 • 308 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 290 citations

Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia

1998 • 276 citations

Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)

1992 • 276 citations

Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance.

1991 • 251 citations

Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA

1997 • 247 citations

A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia

2000 • 245 citations

Flow cytometric analysis of normal B cell differentiation: a frame of reference for the detection of minimal residual disease in precursor-B-ALL

1999 • 237 citations

The biology and treatment of acute lymphoblastic leukemia in adults

1995 • 220 citations

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

1995 • 207 citations

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Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse [see comments]

1991 • 169 citations

New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia

1990 • 154 citations

Review of the incidence and clinical relevance of myeloid antigen-positive acute lymphoblastic leukemia.

1991 • 151 citations

The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors

1995 • 151 citations

Outcome of Philadelphia Chromosome-Positive Adult Acute Lymphoblastic Leukemia

2000 • 146 citations

A new staging system for multiple myeloma based on the number of S- phase plasma cells

1995 • 143 citations

Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92.

1996 • 140 citations

Predictability of the t(1;19)(q23;p13) from surface antigen phenotype: implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis: a Pediatric Oncology Group study

1993 • 128 citations

The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARalpha gene rearrangements.

1999 • 126 citations

Clinically useful information provided by the flow cytometric immunophenotyping of hematological malignancies: current status and future directions.

1999 • 122 citations

Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse [see comments]

1991 • 110 citations

A new staging system for multiple myeloma based on the number of S- phase plasma cells

1995 • 107 citations

Incidence of chromosome numerical changes in multiple myeloma: fluorescence in situ hybridization analysis using 15 chromosome-specific probes.

1996 • 89 citations

Quantitative multiparametric immunophenotyping in acute lymphoblastic leukemia: correlation with specific genotype. I. ETV6/AML1 ALLs identification

2000 • 88 citations

Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a Pediatric Oncology Group study

1998 • 86 citations

Molecular genetics in acute leukemia

2000 • 84 citations

PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl

1996 • 65 citations

The majority of myeloid‐antigen‐positive (My⁺) childhood B‐cell precursor acute lymphoblastic leukaemias express TEL‐AML1 fusion transcripts

1997 • 64 citations

Acute Leukemias with the t(4;11)(q21;q23)

1992 • 62 citations

Acute Lymphoblastic Leukemia (ALL): Detection of Minimal Residual Disease (MRD) at Flow Cytometry

1994 • 60 citations

CONSEQUENCES OF CHROMOSOMAL ABNORMALITIES IN TUMOR DEVELOPMENT

1997 • 60 citations

Expression of CD25 (interleukin-2 receptor α chain) in adult acute lymphoblastic leukemia predicts for the presence of BCR/ABL fusion transcripts: results of a preliminary laboratory analysis of ECOG/MRC Intergroup Study E2993

1997 • 60 citations

THE MOLECULAR BIOLOGY OF CHRONIC MYELOGENOUS LEUKAEMIA

1985 • 60 citations

Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia

1992 • 59 citations

Intensive chemotherapy for Philadelphia-chromosome-positive acute lymphoblastic leukaemia

1994 • 49 citations

A novel monoclonal antibody, KOR-SA3544 which reacts to Philadelphia chromosome-positive acute lymphoblastic leukemia cells with high sensitivity.

1995 • 47 citations

Biology of CD34⁺CD38^-Cells in Lymphohematopoiesis

1998 • 38 citations

Adult Philadelphia-chromosome-positive acute lymphoblastic leukemia: experience of treatments during a ten-year period.

1994 • 36 citations

High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia

1998 • 35 citations

Chromosome abnormalities in CML

1987 • 35 citations

Inhibition of CD10/neutral endopeptidase 24.11 promotes B-cell reconstitution and maturation in vivo.

1993 • 33 citations

The Philadelphia (Ph) chromosome in leukemia. II. Variant Ph translocations in acute lymphoblastic leukemia

1985 • 31 citations

Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity

1998 • 29 citations

Detection of the Mbcr/abl translocation in chronic myeloid leukemia by fluorescence in situ hybridization: Comparison with conventional cytogenetics and implications for minimal residual disease detection

1997 • 25 citations

Effect of the Philadelphia chromosome on minimal residual disease in acute lymphoblastic leukemia

1997 • 22 citations

Chronic myelogenous leukemia: too much or too little growth, or both?

1998 • 7 citations

Current management of acute lymphoblastic leukemia in adults.

1995 • 4 citations