RNA Interference Gene Therapy: A story of mice and men

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA

1999 • 1,702 citations

RNA interference in adult mice

2002 • 1,060 citations

High Levels of Foreign Gene Expression in Hepatocytes after Tail Vein Injections of Naked Plasmid DNA

1999 • 934 citations

Short interfering RNA confers intracellular antiviral immunity in human cells

2002 • 618 citations

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

2002 • 561 citations

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5

1999 • 443 citations

p63 Gene Mutations in EEC Syndrome, Limb-Mammary Syndrome, and Isolated Split Hand–Split Foot Malformation Suggest a Genotype-Phenotype Correlation

2001 • 368 citations

p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

2001 • 286 citations

Monodactylous Limbs and Abnormal Genitalia Are Associated with Hemizygosity for the Human 2q31 Region That Includes the HOXD Cluster

1999 • 98 citations

Heterozygous Mutation in the SAM Domain of p63 Underlies Rapp-Hodgkin Ectodermal Dysplasia

2003 • 74 citations