An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

2000 • 2,694 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

The Conformational Plasticity of Protein Kinases

2002 • 1,691 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

Epidermal growth factor receptor: mechanisms of activation and signalling

2003 • 1,514 citations

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

2003 • 1,509 citations

Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

2002 • 1,308 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains

2002 • 1,158 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Protein Tyrosine Kinase Structure and Function

2000 • 1,117 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Neuregulins: functions, forms, and signaling strategies

2003 • 1,023 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy

1998 • 973 citations

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

2002 • 972 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization

2003 • 764 citations

Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells.

2001 • 760 citations

Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α

2002 • 751 citations

EGF receptor ligands

2003 • 751 citations

Biology of HER2 and Its Importance in Breast Cancer

2001 • 710 citations

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

1994 • 692 citations

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

1996 • 675 citations

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

1999 • 650 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

The ErbB receptors and their role in cancer progression

2003 • 590 citations

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

2003 • 579 citations

The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors

2003 • 578 citations

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

1997 • 482 citations

Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether

2002 • 440 citations

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

1999 • 396 citations

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

1990 • 384 citations

Two EGF molecules contribute additively to stabilization of the EGFR dimer

1997 • 363 citations

Crystal structure of an Eph receptor–ephrin complex

2001 • 330 citations

Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia

2002 • 306 citations

The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes

2002 • 296 citations

Epithelioid and fibroblastic rat kidney cell clones: Epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation

1978 • 296 citations

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

1998 • 253 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

Bivalence of EGF-like ligands drives the ErbB signaling network

1997 • 226 citations

ErbB-targeted therapeutic approaches in human cancer

2003 • 217 citations

Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis.

1994 • 217 citations

Structure-Function relationships for the EGF/TGF-α family of mitogens

1994 • 215 citations

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1989 • 197 citations

Epidermal growth factor receptor

2003 • 182 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor

2003 • 177 citations

Overexpression of HER2/neu in solid tumours: an immunohistochemical survey

2001 • 163 citations

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors

2000 • 146 citations

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors

1987 • 145 citations

A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor

1992 • 121 citations

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

1988 • 119 citations

Autoinhibition Control

2003 • 118 citations

Characterization of Glycosylation Sites of the Epidermal Growth Factor Receptor

2003 • 113 citations

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

1995 • 102 citations

Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics

2002 • 90 citations

Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain

2001 • 89 citations

Disulfide Bond Structure of Human Epidermal Growth Factor Receptor

1998 • 84 citations

Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3

1995 • 76 citations

Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line.

1992 • 75 citations

Identification of a Region within the ErbB2/HER2 Intracellular Domain That Is Necessary for Ligand-independent Association

2002 • 74 citations

The Kinase Domain and Membrane Localization Determine Intracellular Interactions between Epidermal Growth Factor Receptors

1995 • 73 citations

Stoichiometry, Kinetic and Binding Analysis of the Interaction between Epidermal Growth Factor (EGF) and the Extracellular Domain of the EGF Receptor

2000 • 73 citations

The three dimensional structure of the type I insulin-like growth factor receptor

2001 • 71 citations

Perspectives on Anti-HER Monoclonal Antibodies

2002 • 62 citations

Ligand-Binding Enhances the Affinity of Dimerization of the Extracellular Domain of the Epidermal Growth Factor Receptor

1997 • 57 citations

Heregulin Reverses the Oligomerization of HER3

2000 • 50 citations

A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.

1993 • 50 citations

Identification of Residues of the Epidermal Growth Factor Receptor Proximal to Residue 45 of Bound Epidermal Growth Factor

1996 • 43 citations

Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor.

1990 • 43 citations

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

2001 • 43 citations

Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.

1992 • 39 citations

Biochemical characterization of mutant EGF receptors expressed in the hemopoietic cell line BaF/3

1998 • 36 citations

A Discrete Three-amino Acid Segment (LVI) at the C-terminal End of Kinase-impaired ErbB3 Is Required for Transactivation of ErbB2

1999 • 35 citations

Development of Herceptin

2000 • 33 citations

Mutagenesis Reveals a Role for Epidermal Growth Factor Receptor Extracellular Subdomain IV in Ligand Binding

1999 • 32 citations

Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

1990 • 27 citations

HER2 as a Predictor of Therapeutic Response in Breast Cancer

2000 • 25 citations

The deaf and the dumb

2003 • 23 citations