Multiple Interference of Anthracyclines with Mitochondrial Creatine Kinases: Preferential Damage of the Cardiac Isoenzyme and Its Implications for Drug Cardiotoxicity

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis

1992 • 1,958 citations

Role of Quinones in Toxicology

2000 • 1,601 citations

Doxorubicin cardiotoxicity: analysis of prevailing hypotheses

1990 • 688 citations

Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis.

2000 • 472 citations

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1992 • 439 citations

Adriamycin cardiomyopathy: pathophysiology and prevention

1997 • 311 citations

Structure of mitochondrial creatine kinase

1996 • 291 citations

Apoptosis, cancer and cancer therapy

1997 • 286 citations

The role of creatine kinase in inhibition of mitochondrial permeability transition

1997 • 240 citations

Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice.

2000 • 224 citations

Molecular Basis of Anthracycline-Induced Cardiotoxicity and Its Prevention

2000 • 221 citations

Role of iron in anthracycline cardiotoxicity: new tunes for an old song?

1999 • 209 citations

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

1998 • 196 citations

Structure of the adriamycin-cardiolipin complex

1990 • 191 citations

Inhibition of adenosine 5′-triphosphate–creatine phosphotransferase by substrate–anion complexes. Evidence for the transition-state organization of the catalytic site

1971 • 191 citations

Direct Evidence for the Control of Mitochondrial Respiration by Mitochondrial Creatine Kinase in Oxidative Muscle Cells in Situ

2000 • 155 citations

Comparison of the interaction of doxorubicin, daunorubicin, idarubicin and idarubicinol with large unilamellar vesicles

1998 • 140 citations

Cardiotoxicity of doxorubicin and other anthracycline derivatives

2000 • 129 citations

Creatine kinase: The reactive cysteine is required for synergism but is nonessential for catalysis

1993 • 117 citations

Octamers of Mitochondrial Creatine Kinase Isoenzymes Differ in Stability and Membrane Binding

2000 • 114 citations

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.

1998 • 112 citations

Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism

1992 • 106 citations

Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

1998 • 87 citations

The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes

1984 • 85 citations

Crystal structure of human ubiquitous mitochondrial creatine kinase

2000 • 78 citations

Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: suppression of cytochrome c oxidase II gene expression

1999 • 74 citations

Octamer Formation and Coupling of Cardiac Sarcomeric Mitochondrial Creatine Kinase Are Mediated by Charged N-terminal Residues

1998 • 73 citations

Crystal structure of human ubiquitous mitochondrial creatine kinase

2000 • 67 citations

Free radical induced inactivation of creatine kinase: sites of interaction, protection, and recovery

2000 • 63 citations

Site-selective modification of hyperreactive cysteines of ryanodine receptor complex by quinones.

1999 • 61 citations

Interactions of Adriamycin aglycones with mitochondria may mediate Adriamycin cardiotoxicity

1994 • 61 citations

Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture

1999 • 58 citations

Octamer-dimer Transitions of Mitochondrial Creatine Kinase in Heart Disease

1999 • 58 citations

Free radical-induced inactivation of creatine kinase: influence on the octameric and dimeric states of the mitochondrial enzyme (Mib-CK)

1999 • 56 citations

Divergent Enzyme Kinetics and Structural Properties of the Two Human Mitochondrial Creatine Kinase Isoenzymes

2000 • 49 citations

Circular dichroism study

1983 • 46 citations

Mitochondrial Creatine Kinase Interaction with Phospholipid Vesicles

1997 • 37 citations

A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance.

2000 • 34 citations

A spin‐label electron spin resonance study of the binding of mitochondrial creatine kinase to cardiolipin

1989 • 29 citations

Inactivation of creatine kinase by Adriamycin® during interaction with horseradish peroxidase

2000 • 25 citations

Adriamycin-Fe3+-Induced Inactivation of Rat Heart Mitochondrial Creatine Kinase: Sensitivity to Lipid Peroxidation.

1994 • 24 citations

DISTRIBUTION AND TOXIC EFFECTS OF INTRAVENOUSLY INJECTED EPIRUBICIN ON THE CENTRAL NERVOUS SYSTEM OF THE MOUSE

1989 • 11 citations

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