Clinical Relevance of Immunocytochemical Detection of Multidrug-Resistance-Associated P-Glycoprotein in Hematologic Malignancies

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

1983 • 2,745 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Multidrug Resistance1

1988 • 321 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

Clinical trials of agents that reverse multidrug-resistance.

1989 • 176 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

P-glycoprotein and multidrug resistance in cancer chemotherapy.

1989 • 139 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

Multidrug Resistance: Molecular Biology Clinical Relevance

1989 • 114 citations

The multidrug resistance phenotype

1988 • 92 citations

Chromosomal location of human P-glycoprotein gene sequences

1987 • 43 citations

Identification of a multidrug resistance associated antigen (P-glycoprotein) in normal human tissues

1988 • 43 citations

Detection of P-glycoprotein in human leukemias using monoclonal antibodies

1989 • 27 citations

Detection of cells with multidrug-resistant phenotype in myeloproliferative disorders before therapy.

1989 • 13 citations

Detection of drug resistance in human ovarian carcinoma

1989 • 8 citations