The biological basis for conformal three-dimensional radiation therapy

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

The hazard of accelerated tumor clonogen repopulation during radiotherapy

1988 • 1,592 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Growth Kinetics of Tumours

1978 • 691 citations

Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy

1981 • 530 citations

Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves

1985 • 488 citations

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1989 • 487 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

The radioresponsiveness of human tumours and the initial slope ofthe cell survival curve

1984 • 472 citations

The effect of local control on metastatic dissemination in carcinoma of the prostate: Long-term results in patients treated with 1251 implantation

1991 • 462 citations

An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts

1977 • 419 citations

Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.

1989 • 398 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

A multivariate analysis of the prognosis after surgical treatment of malignant soft-tissue tumors

1982 • 370 citations

Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years.

1989 • 357 citations

Heparanases and tumor metastasis

1988 • 303 citations

Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation

1969 • 274 citations

Treatment of the patient with stage M0 soft tissue sarcoma.

1988 • 260 citations

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

1990 • 221 citations

The effect of local-regional control on distant metastatic dissemination in carcinoma of the head and neck: Results of an analysis from the RTOG head and neck database

1991 • 218 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

Boost treatment of the prostate using shaped, fixed fields

1989 • 159 citations

Potential for improving survival rates for the cancer patient by increasing the efficacy of treatment of the primary lesion

1982 • 138 citations

Improved dose distributions for 3d conformal boost treatments in carcinoma of the nasopharynx

1991 • 133 citations

The Significance of Local Control in the Primary Treatment of Breast Cancer

1987 • 132 citations

HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas

1989 • 127 citations

Tumor control in definitive irradiation of localized carcinoma of the prostate

1986 • 126 citations

Keynote address—the problem: Tumor radioresistance in clinical radiotherapy

1982 • 126 citations

Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia.

1989 • 119 citations

Analysis of pelvic tumor control and impact on survival in carcinoma of the uterine cervix treated with radiation therapy alone

1988 • 113 citations

Effect of local tumor control on distant metastasis and survival in prostatic adenocarcinoma

1987 • 108 citations

Definitive irradiation in carcinoma of the vagina: Long-term evaluation of results

1988 • 107 citations

Causes, Time of Death, and Sites of Failure in Squamous-Cell Carcinoma of the Uterine Cervix on Intact Uterus

1967 • 102 citations

Use of body scanner in radiotherapy treatment planning

1977 • 98 citations

Repopulation in Human Tumors: A Biological Back-Ground for Fractionation in Radiotherapy

1988 • 91 citations

Postoperative adjuvant radiotherapy for adenocarcinoma of the rectum and rectosigmoid

1987 • 88 citations

Radiobiological Characterization of 53 Human Tumor Cell Lines

1989 • 87 citations

Cancer Patient Survival Rates: SEER Program Results for 10 Years of Follow-up

1989 • 81 citations

Computed Tomography Applied to Radiotherapy Treatment Planning: Techniques and Results

1979 • 79 citations

Local tumor control and the subsequent incidence of distant metastatic disease

1981 • 78 citations

The Picture Has Changed in the 1980s

1989 • 76 citations

Preliminary report of the National Cancer Data Base

1991 • 75 citations

Metastasis Suppressor Genes

1990 • 75 citations

The utility of computed tomography in radiation therapy: An estimate of outcome

1979 • 75 citations

Biochemical Mechanisms of Tumor Invasion and Metastases

1988 • 74 citations

Treatment of stage I nasopharyngeal carcinoma: Analysis of the patterns of relapse and the results of withholding elective neck irradiation

1989 • 71 citations

Radiation Therapy for Intracranial Lymphoma

1967 • 70 citations

An approach to the interpretation of clinical data on the tumour control probability-dose relationship

1988 • 69 citations

Postoperative adjuvant therapy of rectal cancer: An analysis of disease control, survival, and prognostic factors

1989 • 65 citations

Evaluation of adjuvant postoperative radiotherapy lung cancer

1982 • 64 citations

Development and Use of a Natural History Data Base of Breast Cancer Studies

1987 • 58 citations

Progress in cancer management. Keynote address

1983 • 50 citations

Experimental studies on the incidence of metastases after failure of radiation treatment and the effect of salvage surgery

1988 • 49 citations

Oncogenes and metastatic progression.

1989 • 43 citations

Role of oncogenes in metastases

1988 • 43 citations

The Incidence of Lung Metastases in C3h Mice after Treatment of Implanted Solid Tumours with X-rays or Surgery

1974 • 43 citations

Clinical Interest in Determinations of Cellular Radiation Sensitivity

1989 • 40 citations

Three-dimensional conformal treatment: a new frontier in radiation therapy.

1991 • 40 citations

Increased efficacy of radiation therapy by use of proton beam.

1990 • 40 citations

Treatment of stage I adenocarcinoma of the endometriuim by hysterectomy and adjuvant irradiation: A retrospective analysis of 304 patients

1986 • 40 citations

A study of the influence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behaviour

1975 • 39 citations

The effect of combined modality therapy on local control and survival

1986 • 31 citations

Towards an understanding of the molecular basis of the metastatic phenotype.

1989 • 31 citations

Involvement of heparanase in tumor metastasis and angiogenesis.

1988 • 25 citations

Neu (C-erbB-2) Oncogene in Breast Cancer and its Possible Association with the Risk of Distant Metastases a Retrospective Study and Review of Literature

1990 • 22 citations

Genes controlling the metastatic phenotype.

1988 • 17 citations

Three-dimensional radiation treatment planning.

1989 • 16 citations