Neu (C-erbB-2) Oncogene in Breast Cancer and its Possible Association with the Risk of Distant Metastases a Retrospective Study and Review of Literature

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

Lack of evidence for the prognostic significance of c-erbB-2 amplification in human breast carcinoma.

1988 • 97 citations

Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA.

1988 • 92 citations

Immunohistochemical localization of c-erbB-2 in human breast carcinomas

1987 • 74 citations

Immunohistochemical study of the ras oncogene expression in human breast lesions.

1986 • 39 citations

Amplification and over-expression of the neu oncogene in human breast carcinomas.

1988 • 31 citations

Structure and expression of oncogenes in surgical specimens of human breast carcinomas

1988 • 28 citations

Gene Amplification and Expression of the <i>neu </i>(c-erbB-2) Sequence in Human Mammary Carcinoma

1988 • 27 citations

Oncogenes Give Breast Cancer Prognosis

1987 • 19 citations

The impact of the discovery of oncogenes on cancer mortality rates will come slowly

1987 • 6 citations

Überlegungen zur Aufstellung einer Morbiditätsstatistik der Krebse

1963 • 2 citations