Calcium, neuronal hyperexcitability and ischemic injury

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Calcium Channel

1981 • 1,184 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1984 • 968 citations

Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage‐dependent ionic conductances.

1981 • 960 citations

Calcium messenger system: an integrated view.

1984 • 916 citations

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

1984 • 893 citations

Dominant Role of N-Type Ca ²⁺ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons

1988 • 859 citations

Cortical cellular phenomena in experimental epilepsy: Interictal manifestations

1964 • 838 citations

Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

1984 • 824 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

1985 • 636 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Inactivation of Ca channels

1984 • 616 citations

Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones.

1981 • 555 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies

1983 • 554 citations

Protein Phosphorylation and Neuronal Function

1985 • 525 citations

Immunohistochemical localization of calcium-binding protein in the cerebellum, hippocampal formation and olfactory bulb of the rat

1982 • 491 citations

Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C

1985 • 476 citations

Further study of the role of calcium in synaptic transmission

1970 • 461 citations

Mechanism of Calcium Transport

1985 • 453 citations

Selective Neuronal Vulnerability: Morphological and Molecular Characteristics

1985 • 449 citations

Synaptic Activity Mediates Death of Hypoxic Neurons

1983 • 441 citations

Participation of calcium spikes during intrinsic burst firing in hippocampal neurons

1978 • 425 citations

The stoichiometry of the cardiac sodium-calcium exchange system.

1984 • 425 citations

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

1982 • 421 citations

Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.

1982 • 393 citations

Electrophysiology of Epilepsy

1985 • 392 citations

Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters.

1985 • 361 citations

The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus

1983 • 356 citations

Neurotransmitters, seizures and epilepsy

1982 • 353 citations

Spontaneous and evoked activity of motor nerve endings in calcium Ringer

1969 • 352 citations

Cerebral Protection by Barbiturate Anesthesia

1976 • 333 citations

Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle

1984 • 330 citations

Control, modulation, and regulation of cell calcium

1981 • 330 citations

Are the presynaptic membrane particles the calcium channels?

1981 • 318 citations

Role of calcium in the hormonal regulation of liver metabolism

1981 • 317 citations

Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick

1986 • 316 citations

Probable calcium spikes in hippocampal neurons

1977 • 301 citations

CEREBRAL BLOOD FLOW AND METABOLIC RATE EARLY AND LATE IN PROLONGED EPILEPTIC SEIZURES INDUCED IN RATS BY BICUCULLINE

1976 • 296 citations

Outcome from coma after cardiopulmonary resuscitation

1988 • 289 citations

Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644.

1985 • 285 citations

The effects of 5-minute ischemia in mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes

1983 • 274 citations

Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase.

1985 • 253 citations

Neurochemical Correlates to Selective Neuronal Vulnerability

1985 • 252 citations

Voltage clamp discloses slow inward current in hippocampal burst-firing neurones

1980 • 248 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

The Role of Adenosine in the Regulation of Cerebral Blood Flow

1981 • 236 citations

A MOLECULAR DESCRIPTION OF NERVE TERMINAL FUNCTION

1983 • 229 citations

Barbiturate Protection From Cerebral Infarction in Primates

1975 • 220 citations

CEREBRAL ENERGY METABOLISM DURING EXPERIMENTAL STATUS EPILEPTICUS¹

1975 • 218 citations

Drug action and cellular calcium regulation

1987 • 206 citations

A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures

1979 • 204 citations

Calcium‐activated outward current in voltage‐clamped hippocampal neurones of the guinea‐pig.

1983 • 202 citations

Epileptic Brain Damage: The Role of Systemic Factors That Modify Cerebral Energy Metabolism

1978 • 202 citations

Acid-Base Homeostasis in the Brain: Physiology, Chemistry, and Neurochemical Pathology

1985 • 199 citations

Adenosine agonists reduce voltage‐dependent calcium conductance of mouse sensory neurones in cell culture.

1986 • 188 citations

Seizure-related brain damage induced by cholinergic agents

1983 • 186 citations

The response of GABAergic and cholinergic neurons to transient cerebral ischemia

1982 • 185 citations

CEREBRAL ENERGY METABOLISM DURING TRANSIENT ISCHEMIA AND RECOVERY IN THE GERBIL¹

1977 • 182 citations

Persistent slow inward calcium current in voltage‐clamped hippocampal neurones of the guinea‐pig.

1983 • 174 citations

Focal Cortical Seizures Cause Distant Thalamic Lesions

1982 • 172 citations

Calmodulin in neurotransmitter release and synaptic function.

1982 • 172 citations

Stimulus- and amino acid-induced calcium and potassium changes in rat neocortex

1985 • 171 citations

Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline orl-allylglycine

1983 • 168 citations

A Ca-dependent Cl− conductance in cultured mouse spinal neurones

1984 • 165 citations

The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells

1982 • 164 citations

Simulation of intrinsic bursting in CA3 hippocampal neurons

1982 • 163 citations

Extra- and Intracellular pH in the Brain during Seizures and in the Recovery Period following the Arrest of Seizure Activity

1985 • 162 citations

Selective degeneration of interneurons in the motor cortex of infant monkeys following controlled hypoxia: a possible cause of epilepsy

1980 • 155 citations

A new model of partial status epilepticus based on kindling

1982 • 152 citations

Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes

1983 • 149 citations

Calcium antagonist binding sites in the rat brain: Quantitative autoradiographic mapping using the 1,4-dihydropyridines [3H]PN 200-110 and [3H]PY 108-068

1984 • 148 citations

Repetitive involuntary movement associated with episodic cerebral ischemia

1985 • 146 citations

Metabolic Changes in Cerebral Cortex, Hippocampus, and Cerebellum During Sustained Bicuculline‐Induced Seizures

1981 • 144 citations

Calcium channels and calcium channel antagonists

1987 • 141 citations

Behavioral effects of nimodipine in animals.

1982 • 140 citations

Fast Extracellular Calcium Transients: Involvement in Epileptic Processes

1983 • 138 citations

Epileptic Seizures in Nonembolic Cerebral Infarction

1967 • 136 citations

Evidence for multiple receptor sites within the putative calcium channel

1982 • 134 citations

Epileptic seizures in cerebral arterial occlusive disease.

1982 • 133 citations

Ischemic Brain Damage in Rats following Cardiac Arrest Using a Long-Term Recovery Model

1985 • 130 citations

Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle

1984 • 129 citations

Benzodiazepine and β-adrenergic receptor ligands independently stimulate phospholipid methylation

1979 • 128 citations

Mechanism of Transmitter Release: Voltage Hypothesis and Calcium Hypothesis

1986 • 124 citations

Cerebral energy metabolism, pH, and blood flow during seizures in the cat

1974 • 118 citations

The behavioral effects of the calcium agonist BAY K 8644 in the mouse: Antagonism by the calcium antagonist nifedipine

1985 • 114 citations

What is the function of phospholipid N-methylation?

1983 • 114 citations

Extracellular calcium activity changes in cat sensorimotor cortex induced by iontophoretic application of aminoacids

1980 • 109 citations

Selective Central Nervous System Calcium Channel Blockers—a New Class of Anticonvulsant Agents

1986 • 108 citations

Effects of ischemia-like conditions on cultured neurons: protection by low Na+, low Ca2+ solutions

1986 • 107 citations

Advances in neurology, vol. 34, status epilepticus

1983 • 106 citations

Receptors and phosphoinositide metabolism in the central nervous system

1986 • 104 citations

Widespread distribution of dihydropyridine-sensitive calcium channels in the central nervous system.

1986 • 104 citations

Intracelular sites of early calcium accumulation in the rat hippocampus during status epilepticus

1982 • 104 citations

Epileptic brain damage: pathophysiology and neurochemical pathology.

1986 • 103 citations

Excitatory Transmitters and Epilepsy-Related Brain Damage

1985 • 95 citations

Cerebral protection with barbiturates: relation to anesthetic effect.

1978 • 93 citations

PLASMA MEMBRANE Ca²⁺‐PUMPING ATPases*

1982 • 91 citations

Selective chromatolysis of neurons in the gerbil brain: A possible consequence of “epileptic” activity produced by common carotid artery occlusion

1979 • 87 citations

KAINIC ACID SEIZURES AND THE REVERSIBILITY OF CALCIUM LOADING IN VULNERABLE NEURONS IN THE HIPPOCAMPUS

1984 • 86 citations

Intracellular protein kinase and calcium inward currents in perfused neurones of the snail helix pomatia

1984 • 83 citations

Cell damage in epilepsy and the role of calcium in cytotoxicity.

1986 • 81 citations

A gerbil model of cerebral ischemia suitable for drug evaluation.

1980 • 80 citations

Changes in [Ca2+]o and [K+]o during repetitive electrical stimulation and during pentetrazol induced seizure activity in the sensorimotor cortex of cats

1983 • 79 citations

Suppression of focal epileptiform discharges by intraventricular perfusion of a calcium antagonist

1985 • 78 citations

Substance P augments a persistent slow inward calcium-sensitive current in voltage-clamped spinal dorsal horn neurons of the rat

1986 • 77 citations

Studies on the Mechanism of Action of Diphenylhydantoin

1970 • 76 citations

Physiological Mechanisms of Focal Epileptogenesis

1985 • 76 citations

Ionic shift in cerebral ischemia

1982 • 75 citations

Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker

1986 • 71 citations

Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentration in area CA1 of ‘in vitro’ hippocampal slices of rats

1983 • 71 citations

Motor cortical epileptic foci in vivo: actions of a calcium channel blocker on paroxysmal neuronal depolarizations

1987 • 70 citations

Antiepileptic Effects of a Calcium Antagonist (Nimodipine) on Cefazolin‐Induced Epileptogenic Foci in Rabbits

1986 • 65 citations

Suppression of Pentylenetetrazole Seizures by Oral Administration of a Dihydropyridine Ca²⁺ Antagonist

1987 • 64 citations

Status epilepticus in the limbic system: biochemical and pathological changes.

1983 • 64 citations

Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644

1987 • 64 citations

Open Dose‐Ranging Trial of Flunarizine as Add‐On Therapy in Epilepsy

1985 • 63 citations

Local Chemical, Neural, and Humoral Regulation of Cerebrovascular Resistance Vessels

1985 • 58 citations

Factors influencing calcium movements in rat brain slices

1971 • 57 citations

Receptor-stimulated phosphoinositide metabolism: a role for GTP-binding proteins?

1985 • 53 citations

Cerebral protective, metabolic, and vascular effects of phenytoin.

1980 • 50 citations

Calmodulin systems in neuronal excitability: A molecular approach to epilepsy

1984 • 48 citations

Ischemic Cerebral Edema in Primates

1980 • 47 citations

Barbiturates and nifedipine have different and selective effects on calcium currents of mouse DRG neurons in culture

1988 • 44 citations

Regional Calcium Accumulation and Cation Shifts in Rat Brain by Kainate

1984 • 43 citations

Calcium uptake mechanisms affected by some convulsant and anticonvulsant drugs

1981 • 43 citations

Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx, and histamine release: reconstitution by hybridization.

1981 • 41 citations

Calcitonin and calcitonin gene-related peptide enhance calcium-dependent potentials

1986 • 38 citations

Anoxic Cerebral Potassium Accumulation Reduced by Phenytoin

1981 • 35 citations

Phenytoin interacts with calcium channels in brain membrances

1984 • 34 citations

Isothiouronium compounds as γ‐aminobutyric acid agonists

1986 • 31 citations

Correlation of intracellular redox states and pH with blood flow in primary and secondary seizure foci

1980 • 28 citations

Prostaglandin E1 inhibits calcium-dependent potentials in mammalian sympathetic neurons

1985 • 26 citations

Structure and function in synapses: emerging correlations

1986 • 26 citations

The Significance of Cortical Extracellular H ⁺ , K ⁺ and Ca ²⁺ Activities for Regulation of Local Cerebral Blood Flow under Conditions of Enhanced Neuronal Activity

1978 • 25 citations

Cerebral preservation for intraoperative focal ischemia.

1985 • 21 citations

Epileptogenic mechanisms as revealed by studies of the hippocampal slice

1984 • 21 citations

Effect of D890 on membrane properties of neocortical neurons

1987 • 16 citations

Inactivation of 45Ca2+ uptake by prior depolarization of PC12 cells

1985 • 15 citations

Anticonvulsant Properties of Dihydropyridine Calcium Antagonists

1988 • 12 citations

Calcium Currents in Mammalian Central Neurones

1985 • 6 citations

Epilepsy. A window to brain mechanisms

1982 • 1 citations

Deleted Work

1955 • 0 citations