Antisense inhibition of ras p21 expression that is sensitive to a point mutation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 • 1,028 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

ras oncogenes: their role in neoplasia

1990 • 244 citations

Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression

1992 • 234 citations

Biochemical and biological effects of nonionic nucleic acid methylphosphonates

1981 • 224 citations

Nonionic nucleic acid analogs. Synthesis and characterization of dideoxyribonucleoside methylphosphonates

1979 • 186 citations

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.

1984 • 131 citations

Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA

1988 • 109 citations

Solid-phase synthesis of oligodeoxyribonucleoside methylphosphonates

1986 • 102 citations

Photochemical cross-linking of psoralen-derivatized oligonucleoside methylphosphonates to rabbit globin messenger RNA

1988 • 100 citations

Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents

1985 • 94 citations

Oligodeoxynucleoside methylphosphonates: synthesis and enzymic degradation

1987 • 92 citations

Characterization of sequence-specific oligodeoxyribonucleoside methylphosphonates and their interaction with rabbit globin mRNA

1985 • 79 citations

H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.

1988 • 75 citations

Target dependence of antisense oligodeoxynucleotide inhibition of c-Ha-ras p21 expression and focus formation in T24-transformed NIH3T3 cells.

1990 • 55 citations

Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.

1985 • 45 citations

Chapter 30. Oligonucleotide Inhibitors of Gene Expression in Living Cells: New Opportunities in Drug Design

1988 • 44 citations

Photo-cross-linking of psoralen derivatized oligonucleoside methylphosphonates to single-stranded DNA

1990 • 43 citations

Interaction of psoralen-derivatlzed oligodeoxyribonucleoside methyiphosphonates with synthetic DNA containing a promoter for 11 RNA polymerase

1988 • 41 citations

The genetic origins of human cancer

1988 • 38 citations

c-Ki-ras amplification in human lung cancer

1986 • 34 citations

Modulation of ras expression by anti-sense, nonionic deoxyoligonucleotide analogs.

1989 • 32 citations

An artefact explains the apparent association of the transferrin receptor with a ras gene product

1984 • 22 citations