Na⁺/H⁺ exchangers and the regulation of volume

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger

1998 • 839 citations

TRP channels: An overview

2005 • 721 citations

A possible unifying principle for mechanosensation

2005 • 657 citations

Diversity of the mammalian sodium/proton exchanger SLC9 gene family

2004 • 637 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

PERMEATION AND SELECTIVITY OF TRP CHANNELS

2005 • 532 citations

The Changing Face of the Na⁺/H⁺ Exchanger, NHE1: Structure, Regulation, and Cellular Actions

2002 • 468 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1

2002 • 421 citations

Direct Binding of the Na–H Exchanger NHE1 to ERM Proteins Regulates the Cortical Cytoskeleton and Cell Shape Independently of H+ Translocation

2000 • 407 citations

Volume regulation by Amphiuma red blood cells. The membrane potential and its implications regarding the nature of the ion-flux pathways.

1980 • 359 citations

NHE3: a Na+/H+ exchanger isoform of renal brush border

1993 • 345 citations

Four Na+/H+ Exchanger Isoforms Are Distributed to Golgi and Post-Golgi Compartments and Are Involved in Organelle pH Regulation

2004 • 331 citations

The Diversity of Volume Regulatory Mechanisms

1998 • 310 citations

NHE2 and NHE3 are human and rabbit intestinal brush-border proteins

1996 • 274 citations

Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.

1994 • 257 citations

Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney

1997 • 238 citations

Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7

2004 • 225 citations

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

1992 • 223 citations

The Role of NHERF and E3KARP in the cAMP-mediated Inhibition of NHE3

1998 • 214 citations

Micropuncture analysis of single-nephron function in NHE3-deficient mice

1999 • 168 citations

Human Na⁺/H⁺ exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria

2002 • 168 citations

The NHE1 Na+/H+ Exchanger Recruits Ezrin/Radixin/Moesin Proteins to Regulate Akt-dependent Cell Survival

2004 • 158 citations

Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

1997 • 154 citations

NHERF Associations with Sodium−Hydrogen Exchanger Isoform 3 (NHE3) and Ezrin Are Essential for cAMP-Mediated Phosphorylation and Inhibition of NHE3

2000 • 137 citations

Impaired cell volume regulation in Na(+)-H+ exchange-deficient mutants

1989 • 124 citations

Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II

2003 • 115 citations

The Apical Na+/H+ Exchanger Isoform NHE3 Is Regulated by the Actin Cytoskeleton

1999 • 115 citations

Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines

1996 • 110 citations

Calcium transients and resting levels in isolated smooth muscle cells as monitored with quin 2

1986 • 107 citations

Volume regulation by Necturus gallbladder: apical Na+-H+ and Cl(-)-HCO-3 exchange

1982 • 101 citations

Delineation of Transmembrane Domains of the Na+/H+ Exchanger That Confer Sensitivity to Pharmacological Antagonists

1996 • 100 citations

Sapecin B, a novel fly toxin, blocks macroscopic K+ currents in the GH3 rat pituitary cell line

1997 • 100 citations

Hypertonic activation of AE2 anion exchanger in Xenopus oocytes via NHE-mediated intracellular alkalinization

1995 • 97 citations

Immunolocalization of NHE8 in rat kidney

2004 • 97 citations

Reversible effects of acute hypertension on proximal tubule sodium transporters

1998 • 93 citations

Genomic Organization and Glucocorticoid Transcriptional Activation of the Rat Na+/H+ Exchanger Nhe3 Gene

1996 • 88 citations

Volume regulation by human lymphocytes: Characterization of the ionic basis for regulatory volume decrease

1982 • 87 citations

Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8

2005 • 85 citations

Coordinated regulation of shrinkage-induced Na/H exchange and swelling-induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition.

1991 • 85 citations

Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension

1998 • 82 citations

NHE6 Protein Possesses a Signal Peptide Destined for Endoplasmic Reticulum Membrane and Localizes in Secretory Organelles of the Cell

2001 • 81 citations

Angiotensin II stimulates NHE3 activity by exocytic insertion of the transporter: Role of PI 3-kinase

2003 • 79 citations

Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity

2002 • 79 citations

Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress

1995 • 79 citations

Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods

2004 • 79 citations

Aldosterone stimulates intestinal Na⁺ absorption in rats by increasing NHE3 expression of the proximal colon

1998 • 77 citations

Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction

2003 • 73 citations

Topological analysis of NHE1, the ubiquitous Na⁺/H⁺exchanger using chymotryptic cleavage

1998 • 72 citations

The Isolation and Characterization of a Novel Corticostatin/Defensin-like Peptide from the Kidney

1996 • 70 citations

Effect of high osmolality on Na+/H+ exchange in renal proximal tubule cells.

1994 • 70 citations

The Na+/H+ exchanger gene family.

2002 • 70 citations

Differing effects of cGMP and cAMP on ion transport across flounder intestine

1984 • 69 citations

NHE3 Na⁺/H⁺exchanger supports proximal tubular protein reabsorption in vivo

2004 • 69 citations

Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction

2003 • 67 citations

Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine

2004 • 67 citations

Hyposmolality stimulates apical membrane Na+/H+ exchange and HCO3– absorption in renal thick ascending limb

1999 • 67 citations

Proximal tubule Na transporter responses are the same during acute and chronic hypertension

2000 • 67 citations

Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect

2003 • 66 citations

Hypertonicity Activates Na+/H+ Exchange through Janus Kinase 2 and Calmodulin

2003 • 64 citations

Regulation of NHE3 activity by G protein subunits in renal brush-border membranes

2000 • 60 citations

Osmotic Stimulation of the Na+/H+ Exchanger NHE1: Relationship to the Activation of Three MAPK Pathways

2001 • 59 citations

Luminal hypotonicity: a driving force for fluid absorption from the proximal tubule

1984 • 56 citations

Chronic hyperosmolality increases NHE3 activity in OKP cells.

1998 • 53 citations

Effect of angiotensin-II on renal Na+/H+ exchanger-NHE3 and NHE2

2004 • 52 citations

Hyposmolality stimulates Na⁺/H⁺exchange and HCO₃⁻absorption in thick ascending limb via PI 3-kinase

2000 • 51 citations

Effects of ionic strength on the regulation of Na/H exchange and K-Cl cotransport in dog red blood cells.

1995 • 47 citations

Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension

2002 • 47 citations

Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells

1998 • 43 citations

Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders

2003 • 39 citations

Lithium clearance during the paradoxical natriuresis of hypotonic expansion in man

1987 • 39 citations

α₁-Adrenergic receptors activate NHE1 and NHE3 through distinct signaling pathways in epithelial cells

2001 • 39 citations

Activation of Na+/H+ Exchange Is Required for Regulatory Volume Decrease after Modest “Physiological” Volume Increases in Jejunal Villus Epithelial Cells

1996 • 35 citations

Na+/H+ exchange in volume regulation and cytoplasmic pH homeostasis in lymphocytes.

1985 • 34 citations

Regulation of proximal tubule sodium/hydrogen antiporter with chronic volume contraction

2001 • 28 citations

Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance

2003 • 25 citations

Examination of the role for Ca2+ in regulation and phosphorylation of the Na+/H+ antiporter NHE1 via mitogen and hypertonic stimulation

1996 • 25 citations

Extracellular Na⁺inhibits Na⁺/H⁺exchange: cell shrinkage reduces the inhibition

2004 • 25 citations

Evidence for Involvement of the Putative First Extracellular Loop in Differential Volume Sensitivity of the Na⁺/H⁺ Exchangers NHE1 and NHE2

2003 • 24 citations

Anion exchanger isoform 2 operates in parallel with Na⁺/H⁺ exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells

2002 • 16 citations

Introduction to Cell Volume Regulatory Mechanisms

1998 • 15 citations

Effect of dehydration on apical Na + -H + exchange activity and Na + -dependent sugar transport in brush-border membrane vesicles isolated from chick intestine

1998 • 14 citations

Diminished Expression of Sodium Transporters in the Ureteral Obstructed Kidney in Rats

2004 • 9 citations

Transport of solute in proximal tubules is modified by changes in medium osmolality

1986 • 8 citations

[Effect of angiotensin ii on Na+/H+ exchangers of the renal tubule].

1998 • 6 citations

Cell shrinkage activates Na+/H+ exchange in dog red cells by relieving inhibition of exchange by Na+ in isotonic medium

2004 • 5 citations