The interaction of the cell-contact proteins VASP and vinculin is regulated by phosphatidylinositol-4,5-bisphosphate

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

A 130K protein from chicken gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells

1979 • 794 citations

Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics

1996 • 667 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.

1994 • 451 citations

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

1997 • 414 citations

A rapid purification of alpha-actinin, filamin, and a 130,000-dalton protein from smooth muscle.

1980 • 395 citations

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.

1992 • 374 citations

F-actin binding site masked by the intramolecular association of vinculin head and tail domains

1995 • 371 citations

Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.

1992 • 344 citations

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.

1993 • 335 citations

Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

1992 • 320 citations

A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells.

1995 • 272 citations

Vinculin Is Part of the Cadherin–Catenin Junctional Complex: Complex Formation between α-Catenin and Vinculin

1998 • 260 citations

Phosphorylation of Focal Adhesion Vasodilator‐Stimulated Phosphoprotein at Ser157 in Intact Human Platelets Correlates with Fibrinogen Receptor Inhibition

1994 • 251 citations

Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA.

1992 • 228 citations

Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin.

1992 • 224 citations

An intramolecular association between the head and tail domains of vinculin modulates talin binding.

1994 • 212 citations

Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP.

1995 • 208 citations

The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin

1996 • 196 citations

Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein).

1995 • 185 citations

Vinculin is essential for muscle function in the nematode.

1991 • 173 citations

Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions.

1991 • 167 citations

Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin.

1994 • 154 citations

VASP interaction with vinculin: a recurring theme of interactions with proline‐rich motifs

1996 • 152 citations

Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites

1996 • 150 citations

Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells

1992 • 149 citations

β-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways

1994 • 118 citations

Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation

1996 • 113 citations

Intramolecular interactions in vinculin control α‐actinin binding to the vinculin head

1994 • 105 citations

Role of Cyclic Nucleotide-Dependent Protein Kinases and Their Common Substrate VASP in the Regulation of Human Platelets

1993 • 104 citations

Characterization of Two F‐Actin‐Binding and Oligornerization Sites in the Cell‐Contact Protein Vinculin

1997 • 99 citations

Molecular shape and self‐association of vinculin and metavinculin

1985 • 86 citations

Actin binding proteins — lipid interactions

1991 • 86 citations

Molecular mechanisms for focal adhesion assembly through regulation of protein–protein interactions

1996 • 79 citations

The Carboxy-Terminal Tail Domain of Vinculin Contains a Cryptic Binding Site for Acidic Phospholipids

1995 • 74 citations

Interaction of the cytoskeletal component vinculin with bilayer structures analyzed with a photoactivatable phospholipid.

1986 • 69 citations

Vinculin Proteolysis Unmasks an ActA Homolog for Actin-based Shigella Motility

1997 • 68 citations

Interaction of the 47-kDa talin fragment and the 32-kDa vinculin fragment with acidic phospholipids: a computer analysis

1995 • 57 citations

Actin and cell pathogenesis

1997 • 53 citations

Actin-based bacterial motility: towards a definition of the minimal requirements

1996 • 53 citations

Ligand recruitment by vinculin domains in transfected cells

1997 • 43 citations

Integrin-Dependent Control of Inositol Lipid Synthesis in Vascular Endothelial Cells and Smooth Muscle Cells

1996 • 39 citations

Intramolecular interactions regulate serine/threonine phosphorylation of vinculin

1996 • 32 citations