Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

2008 • 1,695 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Retinoic Acid Imprints Gut-Homing Specificity on T Cells

2004 • 1,460 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

2003 • 1,058 citations

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

2007 • 968 citations

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

2006 • 963 citations

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

2007 • 846 citations

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

2006 • 814 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

2005 • 797 citations

A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

2007 • 789 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

2007 • 768 citations

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

2008 • 721 citations

Foxp3 in control of the regulatory T cell lineage

2007 • 690 citations

Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells

2006 • 676 citations

Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma

2005 • 675 citations

Th17 Cell Differentiation: The Long and Winding Road

2008 • 675 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing

2005 • 651 citations

Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand

2007 • 614 citations

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

2005 • 583 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

Oral tolerance

2005 • 573 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

2008 • 509 citations

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

2007 • 477 citations

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

2005 • 474 citations

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

2006 • 463 citations

Intestinal villous M cells: An antigen entry site in the mucosal epithelium

2004 • 455 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells

2008 • 452 citations

Breast milk–mediated transfer of an antigen induces tolerance and protection from allergic asthma

2008 • 428 citations

PD-1 and its ligands in T-cell immunity

2007 • 419 citations

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

2008 • 418 citations

Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells

2001 • 408 citations

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

2008 • 393 citations

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

2006 • 390 citations

‘Yin–Yang’ functions of transforming growth factor‐β and T regulatory cells in immune regulation

2007 • 356 citations

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

2003 • 335 citations

Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells

2008 • 324 citations

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

2003 • 308 citations

Oral Tolerance: Therapeutic Implications for Autoimmune Diseases

2006 • 253 citations

CD11b+ Peyer’s Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells

2003 • 241 citations

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

2004 • 240 citations

Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25−LAP+ T cells

2006 • 238 citations

Mucosal CD8α⁺ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties

2003 • 231 citations

CD4+CD25− T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-β-Dependent Mechanism

2003 • 224 citations

Immunomodulatory dendritic cells in intestinal lamina propria

2005 • 224 citations

A Kinetic and Dynamic Analysis of Foxp3 Induced in T Cells by TGF-β

2007 • 198 citations

Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.

2006 • 175 citations

Rapamycin and Interleukin-10 Treatment Induces T Regulatory Type 1 Cells That Mediate Antigen-Specific Transplantation Tolerance

2006 • 168 citations

CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

2007 • 161 citations

Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell–mediated effects on regulatory T cells

2008 • 160 citations

Gastrointestinal Dendritic Cells Promote Th2 Skewing via OX40L

2008 • 160 citations

Regulation of T cell activation and tolerance by PDL2

2006 • 159 citations

Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease

2005 • 153 citations

The functional interactions of commensal bacteria with intestinal secretory IgA

2007 • 150 citations

Cutting Edge: Peyer’s Patch Plasmacytoid Dendritic Cells (pDCs) Produce Low Levels of Type I Interferons: Possible Role for IL-10, TGFβ, and Prostaglandin E2 in Conditioning a Unique Mucosal pDC Phenotype

2007 • 146 citations

In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance

2005 • 145 citations

Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGFβ-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis

2008 • 140 citations

Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells

2008 • 119 citations

Functional CD25^– and CD25⁺ mucosal regulatory T cells are induced in gut‐draining lymphoid tissue within 48 h after oral antigen application

2003 • 117 citations

Oral Tolerance Induction with Antigen Conjugated to Cholera Toxin B Subunit Generates Both Foxp3+CD25+ and Foxp3−CD25− CD4+ Regulatory T Cells

2006 • 112 citations

TGF-β1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets

2007 • 111 citations

Immunological mechanisms of sublingual immunotherapy

2006 • 109 citations

Oral Tolerance and TGF-β -Producing Cells

2006 • 107 citations

Interleukin‐10‐secreting Peyer's patch cells are responsible for active suppression in low‐dose oral tolerance

2001 • 105 citations

Induction of Ovalbumin-Specific Tolerance by Oral Administration of Lactococcus lactis Secreting Ovalbumin

2007 • 103 citations

IL‐10‐dependent partial refractoriness to Toll‐like receptor stimulation modulates gut mucosal dendritic cell function

2008 • 102 citations

Human Peyer’s Patch T Cells Are Sensitized to Dietary Antigen and Display a Th Cell Type 1 Cytokine Profile

2000 • 92 citations

Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

2008 • 91 citations

LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism

2007 • 84 citations

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

2008 • 83 citations

Development of intestinal M cells

2005 • 80 citations

Oral tolerance and regulation of mucosal immunity.

2005 • 76 citations

The ICOS Molecule Plays a Crucial Role in the Development of Mucosal Tolerance

2005 • 75 citations

FcγRIIB Regulates Nasal and Oral Tolerance: A Role for Dendritic Cells

2005 • 74 citations

A key role for CCR7 in establishing central and peripheral tolerance

2007 • 74 citations

Antigen‐induced, tolerogenic CD11c+,CD11b+ dendritic cells are abundant in Peyer's patches during the induction of oral tolerance to type II collagen and suppress experimental collagen‐induced arthritis

2006 • 69 citations

Cutting Edge: Immunosuppressant as Adjuvant for Tolerogenic Immunization

2008 • 62 citations

Antigen-specific, CD4+CD25+ regulatory T cell clones induced in Peyer's patches

2003 • 61 citations

Intestinal epithelial barrier and mucosal immunity

2005 • 60 citations

Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model

2008 • 57 citations

The importance of regional lymph nodes for mucosal tolerance

2006 • 53 citations

CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype

2008 • 49 citations

Role of intestinal bacterial flora in oral tolerance induction.

2004 • 42 citations

Mucosally Induced Systemic T Cell Unresponsiveness to Ovalbumin Requires CD40 Ligand-CD40 Interactions

1999 • 42 citations

Regulatory role of Peyer’s patches for the inhibition of OVA-induced allergic diarrhea

2007 • 37 citations

Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease

2006 • 35 citations

Bystander suppression of collagen-induced arthritis in mice fed ovalbumin

2004 • 20 citations

Antigen-Specific CD4+ Regulatory T Cells in the Intestine

2006 • 20 citations

Induction of Bystander Suppression by Feeding Antigen Occurs despite Normal Clonal Expansion of the Bystander T Cell Population

2004 • 18 citations

IL-18 and Antigen-Specific CD4⁺Regulatory T Cells in Peyer's Patches

2004 • 11 citations

New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by regulatory T cells

2005 • 4 citations