NK and CD8⁺ T cell‐mediated eradication of poorly immunogenic B16‐F10 melanoma by the combined action of IL‐12 gene therapy and 4‐1BB costimulation

Cancer Statistics, 2001

2001 • 3,342 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Cancer statistics, 1996

1996 • 1,807 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells

2002 • 986 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

2001 • 743 citations

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

2002 • 713 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells

2002 • 704 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 491 citations

gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand

1998 • 490 citations

Immune surveillance against a solid tumor fails because of immunological ignorance

1999 • 463 citations

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

2002 • 424 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

2002 • 285 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 282 citations

Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity

2002 • 277 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 265 citations

Cytokines and Immune Response in the Tumor Microenvironment

2001 • 250 citations

Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells

2000 • 245 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

1996 • 237 citations

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

1996 • 231 citations

Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells

2002 • 231 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 219 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 215 citations

Depletion of CD4+CD25+ Regulatory Cells Augments the Generation of Specific Immune T Cells in Tumor-Draining Lymph Nodes

2002 • 206 citations

Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28.

1995 • 181 citations

Metastatic melanoma: Chemotherapy

2002 • 162 citations

Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile

1998 • 154 citations

Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses

1998 • 131 citations

Clonal analysis of cytotoxic and regulatory T cell responses against human melanoma.

1989 • 130 citations

Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.

2000 • 127 citations

CD4 T cells inhibit in vivo the CD8‐mediated immune response against murine colon carcinoma cells transduced with interleukin‐12 genes

1995 • 125 citations

Divergent Roles for CD4+ T Cells in the Priming and Effector/Memory Phases of Adoptive Immunotherapy

2000 • 114 citations

ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival

1996 • 109 citations

Systemic chemotherapy for the treatment of metastatic melanoma.

2002 • 101 citations

Antitumor activity of interleukin 12 in preclinical models

1996 • 94 citations

Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation.

2001 • 92 citations

In Vivo Triggering Through 4-1BB Enables Th-Independent Priming of CTL in the Presence of an Intact CD28 Costimulatory Pathway

2002 • 92 citations

Rejection of Disseminated Metastases of Colon Carcinoma by Synergism of IL-12 Gene Therapy and 4-1BB Costimulation

2000 • 88 citations

Selective MHC expression in tumours modulates adaptive and innate antitumour responses

1999 • 83 citations

Role of NK and T cells in IL-12-induced anti-tumor response against hepatic colon carcinoma

1999 • 79 citations

Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response.

1990 • 75 citations

Administration of interleukin-12 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines in mouse hepatocellular carcinoma.

2001 • 75 citations

Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism

2000 • 67 citations

Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.

1998 • 65 citations

Elimination of CD4+ T Cells Enhances Anti-Tumor Effect of Locally Secreted Interleukin-12 on B16 Mouse Melanoma and Induces Vitiligo-Like Coat Color Alteration

2000 • 65 citations

Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes

2001 • 58 citations

Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation

2004 • 55 citations

T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer

2002 • 54 citations

Antitumor Activities of IL-12 and Mechanisms of Action

1997 • 54 citations

CD4⁺ helper T cells are required for resistance to a highly metastatic murine tumor

1987 • 53 citations

Dendritic cell-tumor coculturing vaccine can induce antitumor immunity through both NK and CTL interaction

2001 • 42 citations

Interleukin 12 Gene Transfer into Skin Distant from the Tumor Site Elicits Antimetastatic Effects Equivalent to Local Gene Transfer

2001 • 28 citations

Systemic administration of interleukin-12 can restore the anti-tumor potential of B16 melanoma-draining lymph node cells impaired at a late tumor-bearing state

1998 • 20 citations

Biochemotherapy of melanoma

2002 • 15 citations

T-cell subset analysis of Lewis lung carcinoma tumor rejection: heterogeneity of effectors and evidence for negative regulatory lymphocytes correlating with metastasis.

1992 • 14 citations

Therapeutic Potential of 4-1BB (CD137) As a Regulator for Effector CD8⁺T Cells

2001 • 12 citations

B7.1 expression eliminates tumor resistance to IL-12 gene therapy

2001 • 8 citations