Recent developments in the use of chemotherapy in brain tumours

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

2005 • 18,835 citations

MGMTGene Silencing and Benefit from Temozolomide in Glioblastoma

2005 • 6,591 citations

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic Oligodendrogliomas

1998 • 1,611 citations

Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials

2002 • 1,233 citations

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

2000 • 940 citations

Abbreviated Course of Radiation Therapy in Older Patients With Glioblastoma Multiforme: A Prospective Randomized Clinical Trial

2004 • 840 citations

MGMT: its role in cancer aetiology and cancer therapeutics

2004 • 788 citations

Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide

2002 • 777 citations

Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide

2004 • 769 citations

Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

1999 • 762 citations

Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study

2002 • 606 citations

Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group.

1994 • 448 citations

Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Temozolomide in Malignant Glioma Patients

2004 • 447 citations

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

1998 • 413 citations

Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse

2001 • 373 citations

Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules

2003 • 365 citations

Temozolomide As Initial Treatment for Adults With Low-Grade Oligodendrogliomas or Oligoastrocytomas and Correlation With Chromosome 1p Deletions

2004 • 357 citations

Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma

1999 • 353 citations

Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide

2002 • 338 citations

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

1998 • 300 citations

Phase II Study of First-Line Chemotherapy With Temozolomide in Recurrent Oligodendroglial Tumors: The European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971

2003 • 296 citations

Phase I Trial of Temozolomide Plus O⁶-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2005 • 288 citations

Phase I trial of temozolomide using an extended continuous oral schedule.

1998 • 284 citations

Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors

2004 • 271 citations

Phase II study of primary temozolomide chemotherapy in patients with WHO grade II gliomas

2003 • 260 citations

Selective CD4⁺ Lymphopenia in Melanoma Patients Treated With Temozolomide: A Toxicity With Therapeutic Implications

2004 • 259 citations

Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response

2003 • 255 citations

Phase II Trial of Temozolomide in Patients With Progressive Low-Grade Glioma

2003 • 248 citations

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.

1996 • 245 citations

Phase II Trial of Procarbazine, Lomustine, and Vincristine as Initial Therapy for Patients With Low-Grade Oligodendroglioma or Oligoastrocytoma: Efficacy and Associations With Chromosomal Abnormalities

2003 • 245 citations

Phase II Trial of Temozolomide Plus the Matrix Metalloproteinase Inhibitor, Marimastat, in Recurrent and Progressive Glioblastoma Multiforme

2002 • 210 citations

Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies

1999 • 205 citations

Response rate and prognostic factors of recurrent oligodendroglioma treated with procarbazine, CCNU, and vincristine chemotherapy

1998 • 200 citations

Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features

2003 • 197 citations

Phase II Trial of Carmustine Plus O⁶-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma

2002 • 191 citations

Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas

2003 • 175 citations

Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972

2003 • 166 citations

One week on/one week off: A novel active regimen of temozolomide for recurrent glioblastoma

2004 • 157 citations

Phase II Evaluation of Temozolomide and 13-cis-Retinoic Acid for the Treatment of Recurrent and Progressive Malignant Glioma: A North American Brain Tumor Consortium Study

2003 • 151 citations

Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations

2004 • 139 citations

Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas

2003 • 138 citations

How effective is BCNU in recurrent glioblastoma in the modern era?

2004 • 132 citations

Successful treatment of low‐grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine

2005 • 128 citations

Second-Line Chemotherapy With Irinotecan Plus Carmustine in Glioblastoma Recurrent or Progressive After First-Line Temozolomide Chemotherapy: A Phase II Study of the Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)

2004 • 120 citations

PCV chemotherapy for recurrent glioblastoma multiforme

2001 • 117 citations

Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2000 • 112 citations

First-Line Chemotherapy With Cisplatin Plus Fractionated Temozolomide in Recurrent Glioblastoma Multiforme: A Phase II Study of the Gruppo Italiano Cooperativo di Neuro-Oncologia

2004 • 104 citations

A phase II study of extended low-dose temozolomide in recurrent malignant gliomas

2002 • 104 citations

Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain.

1993 • 101 citations

Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas

2004 • 84 citations

Multicentre phase II study and pharmacokinetic analysis of irinotecan in chemotherapy-naïve patients with glioblastoma

2003 • 82 citations

A phase II study of extended low-dose temozolomide in recurrent malignant gliomas

2002 • 81 citations

Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase.

2001 • 79 citations

Salvage chemotherapy with CPT-11 for recurrent glioblastoma multiforme.

2002 • 76 citations

Intracellular localization and intercellular heterogeneity of the human DNA repair protein O 6 -methylguanine-DNA methyltransferase

1996 • 68 citations

Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors

2003 • 68 citations

Pneumocystis carinii pneumonia in HIV negative patients with primary brain tumors.

2003 • 66 citations

Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas.

1994 • 66 citations

Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study

2004 • 66 citations

Human papillomavirus DNA and antibodies to human papillomaviruses 16 E2, L2, and E7 peptides as predictors of survival in patients with squamous cell cervical cancer.

1997 • 44 citations

An intergroup randomized controlled clinical trial (RCT) of chemotherapy plus radiation (RT) versus RT alone for pure and mixed anaplastic oligodendrogliomas: Initial report of RTOG 94–02

2004 • 43 citations

Dose-dense regimen of temozolomide given every other week in patients with primary central nervous system tumors

2003 • 35 citations

A phase I trial of 1,3-bis(2-chloroethyl)-1-nitrosourea plus temozolomide: A North American Brain Tumor Consortium study

2000 • 35 citations

An intergroup randomized controlled clinical trial (RCT) of chemotherapy plus radiation (RT) versus RT alone for pure and mixed anaplastic oligodendrogliomas: Initial report of RTOG 94–02

2004 • 24 citations