Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase.

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1997 • 777 citations

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

1998 • 413 citations

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

1996 • 236 citations

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

1993 • 195 citations

Phase I and Pharmacokinetic Study of Temozolomide on a Daily-for-5-Days Schedule in Patients With Advanced Solid Malignancies

1999 • 121 citations

Antitumour imidazotetrazines—XV

1987 • 115 citations

DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents.

1986 • 108 citations

O6-Methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

1998 • 88 citations

Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide

1994 • 87 citations

Effect of single and multiple administration of an O ? 6 -benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

1997 • 59 citations

Determination of temozolomide in human plasma and urine by high-performance liquid chromatography after solid-phase extraction

1995 • 55 citations

Phase I Study of Streptozocin- and Carmustine-Sequenced Administration in Patients With Advanced Cancer

1992 • 46 citations

Modulation of nitrosourea resistance in myeloid leukemias

1988 • 39 citations

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

1989 • 39 citations

Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers.

1995 • 27 citations