Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans

1983 • 465 citations

Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

1998 • 323 citations

Carcinogenicity of polycyclic aromatic hydrocarbons

2005 • 310 citations

Polynuclear aromatic compounds, Part 1, Chemical, environmental and experimental data.

1983 • 285 citations

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Volume 32. Polynuclear Aromatic Compounds, Part 1, Chemical, Environmental and Experimental Data

1985 • 224 citations

Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer.

2003 • 211 citations

Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene.

1986 • 170 citations

Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis

2008 • 163 citations

Five Glutathione S-Transferase Gene Variants in 23,452 Cases of Lung Cancer and 30,397 Controls: Meta-Analysis of 130 Studies

2006 • 149 citations

Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

1997 • 106 citations

Glutathione Conjugation and DNA Adduct Formation of Dibenzo[a,l]pyrene and Benzo[a]pyrene Diol Epoxides in V79 Cells Stably Expressing Different Human Glutathione Transferases

2002 • 100 citations

Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.

1999 • 88 citations

CARCINOGENESIS: Glutathione S-transferase A1–1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione

1996 • 84 citations

Meta- and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer: A HuGE-GSEC Review

2009 • 76 citations

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans:

1984 • 60 citations

Polynuclear aromatic compounds, Part 4, Bitumens, coal-tars and derived products, shale-oils and soots.

1985 • 59 citations

CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene–gene interactions

2004 • 58 citations

Overexpression of Stably Transfected Human GlutathioneS-Transferase P1–1 Protects against DNA Damage by Benzo[a]pyrene Diol-Epoxide in Human T47D Cells

1998 • 55 citations

Effects of glutathione transferase activity on benzo[a]pyrene 7,8-dihydrodiol metabolism and mutagenesis studied in a mammalian cell co-cultivation assay

1989 • 45 citations

Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells

1998 • 31 citations

Genotoxicity characteristics of reverse diol-epoxides of chrysene

1993 • 29 citations

Metabolic Fate of Glutathione Conjugate of Benzo[a]pyrene-(7R,8S)-diol (9S,10R)-epoxide in Human Liver

1999 • 25 citations

Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1

2006 • 25 citations

Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S -transferase polymorphisms

2008 • 22 citations

Polycyclic Aromatic Hydrocarbon-Induced Carcinogenesis – An Introduction

2005 • 19 citations

Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared to a Bay Region Diol Epoxide of Phenanthrene in Human Hepatocytes: Relevance to Molecular Epidemiology Studies of Glutathione-S-Transferase Polymorphisms and Cancer

2009 • 17 citations

Quantitation of N-Acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-<scp>l</scp>-cysteine in Human Urine: Comparison with Glutathione-S-transferase Genotypes in Smokers

2006 • 16 citations

Protective Efficacy of hGSTM1-1 against B[a]P and (+)- or ( )-B[a]P-7,8-Dihydrodiol Cytotoxicity, Mutagenicity, and Macromolecular Adducts in V79 Cells Coexpressing hCYP1A1

2007 • 16 citations

Glutathione transferase catalyzed conjugation of benzo[a]pyrene 7,8-diol 9,10-epoxide with glutathione in human skin

1989 • 11 citations