T Cell‐Mediated Production of Tumour Necrosis Factor‐α by Monocytes

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

1985 • 492 citations

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

1983 • 447 citations

Human interleukin 1 is a cytocidal factor for several tumor cell lines.

1985 • 380 citations

Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes.

1978 • 379 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Activation of human macrophages. Comparison of other cytokines with interferon-gamma.

1984 • 362 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.

1986 • 241 citations

Characterization of Lymphocyte-Activating Factor (LAF) Produced by the Macrophage Cell Line, P388D1

1978 • 237 citations

Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes.

1985 • 217 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes.

1987 • 178 citations

Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS.

1978 • 172 citations

Production of intra- and extracellular interleukin-1 (IL-1) by human monocytes

1984 • 114 citations

Interferons as macrophage‐activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide‐stimulated human monocytes

1983 • 112 citations

Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin.

1986 • 105 citations

Characterization of Lymphocyte-Activating Factor (LAF) Produced by a Macrophage Cell Line, P388D1

1978 • 85 citations

Lipopolysaccharide (LPS) stimulates fresh human monocytes to lyse actinomycin D-treated WEHI-164 target cells via increased secretion of a monokine similar to tumor necrosis factor.

1985 • 79 citations

T cell induction of membrane IL 1 on macrophages.

1986 • 77 citations

Macrophage activation for tumor cytotoxicity: induction of macrophage tumoricidal activity by lymphokines from EL-4, a continuous T cell line.

1982 • 74 citations

Protein changes associated with stages of activation of mouse macrophages for tumor cell killing.

1986 • 52 citations

Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate‐induced peritoneal murine macrophages

1986 • 52 citations

Characteristics of bacterial lipopolysaccharide induction of interleukin 1 synthesis and secretion by human monocytes.

1986 • 47 citations

Interleukin 2 induction of interferon-gamma mRNA synthesis.

1986 • 46 citations

Interferon as a macrophage activating factor. I. Enhancement of cytotoxicity by fresh and matured human monocytes in the absence of other soluble signals.

1983 • 40 citations

Recombinant Interferon-γ Stimulates the Production of Human Tumor Necrosis FactorIn Vitro

1987 • 31 citations

Immune interferon induction by a monoclonal antibody specific for human T cells

1981 • 20 citations

Analysis of deficiencies in IFN-gamma-mediated priming for tumor cytotoxicity in peritoneal macrophages from A/J mice.

1986 • 20 citations

Identification of a human monocyte cytotoxicity-inducing factor from T cell hybridomas produced from Sezary's cells.

1986 • 15 citations

The mechanism of action of lymphokines. IX. The enzymatic basis of hydrogen peroxide production by lymphokine-activated macrophages.

1986 • 9 citations