Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Neurosecretion and Brain Peptides

1982 • 458 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Nuclear Proto-Oncogenes Fos and Jun

1990 • 392 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.

1987 • 381 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens.

1987 • 292 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.

1988 • 266 citations

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

1990 • 235 citations

8 Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development

1990 • 219 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin

1983 • 208 citations

Histomorphological Basis of Articular Cartilage Destruction in Rheumatoid Arthritis

1983 • 195 citations

Early transcriptional events in cell growth

1990 • 192 citations

Enhanced expression of TGF-β and c-fos mRNAs in the growth plates of developing human long bones

1988 • 173 citations

5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene

1988 • 158 citations

Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues

1990 • 143 citations

Expression of the Collagenolytic and Ras-Induced Cysteine Proteinase Cathepsin L and Proliferation-Associated Oncogenes in Synovial Cells of MRL/I Mice and Patients with Rheumatoid Arthritis

1990 • 134 citations

Mechanisms of Matrix Degradation in Rheumatoid Arthritis^a

1990 • 132 citations

Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the amino-terminal end of the activated enzyme

1988 • 91 citations

Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid

1982 • 73 citations

c-fos expression precedes osteogenic differentiation of cartilage cells in vitro.

1990 • 71 citations

Antisense RNA of Proto-Oncogene c-fos Blocks Renewed Growth of Quiescent 3T3 Cells

1987 • 70 citations

Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes

1989 • 67 citations

From tadpole collagenase to a family of matrix metalloproteinases

1988 • 65 citations

Molecular autoimmunity

1992 • 64 citations

Expression of a Zinc Finger Gene in HTLV-I- and HTLV-II-Transformed Cells

1990 • 62 citations

Cellular basis and oncogene expression of rheumatoid joint destruction

1989 • 55 citations

Microinjection of fos-Specific Antibodies Blocks DNA Synthesis in Fibroblast Cells

1988 • 52 citations

Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin.

1989 • 51 citations

cDNA sequence of the human cellular early growth response gene Egr-1

1990 • 51 citations

Etiopathogenesis of rheumatoid arthritis-like disease in MRL/1 mice: II. Ultrastructural basis of joint destruction.

1988 • 48 citations

Expression of collagenase and potential transcriptional factors in the MRL/1 mouse arthropathy

1992 • 16 citations

The role of nerve growth factor (NGF) and related factors for the survival of peripheral neurons.

1981 • 15 citations

The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase.

1990 • 7 citations