BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

2003 • 10,537 citations

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

2011 • 7,390 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2010 • 3,500 citations

Systematic identification of genomic markers of drug sensitivity in cancer cells

2012 • 2,310 citations

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

2010 • 2,120 citations

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

2012 • 2,111 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

2008 • 1,820 citations

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

2010 • 1,767 citations

High frequency of BRAF mutations in nevi

2002 • 1,701 citations

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

2012 • 1,673 citations

Mouse genomic variation and its effect on phenotypes and gene regulation

2011 • 1,532 citations

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

2005 • 1,478 citations

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

2010 • 1,438 citations

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

2011 • 1,378 citations

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

2008 • 1,305 citations

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

2010 • 1,218 citations

BrafV600E cooperates with Pten loss to induce metastatic melanoma

2009 • 1,119 citations

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

2012 • 1,094 citations

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

2013 • 908 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

2002 • 728 citations

BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

2005 • 653 citations

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

2011 • 634 citations

MEK1 mutations confer resistance to MEK and B-RAF inhibition

2009 • 622 citations

Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance

2012 • 609 citations

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

2009 • 554 citations

PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression

2011 • 521 citations

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system

2005 • 485 citations

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

2011 • 448 citations

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

2013 • 434 citations

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

2005 • 405 citations

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

2005 • 404 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

2013 • 332 citations

Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

2003 • 324 citations

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

2012 • 307 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1999 • 258 citations

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

1998 • 239 citations

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition

2013 • 208 citations

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

2008 • 203 citations

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

2011 • 186 citations

Akt3-Mediated Resistance to Apoptosis in B-RAF–Targeted Melanoma Cells

2010 • 184 citations

Characterization of melanocyte‐specific inducible Cre recombinase transgenic mice

2006 • 161 citations

A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites

2009 • 160 citations

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma

2013 • 133 citations

Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms

1999 • 128 citations

Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis

2009 • 120 citations

Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens

2006 • 119 citations

IGF1 Promotes Resistance to Apoptosis in Melanoma Cells through an Increased Expression of BCL2, BCL-X(L), and Survivin

2007 • 105 citations

Mutant B-RAF mediates resistance to anoikis via Bad and Bim

2008 • 102 citations

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

2013 • 99 citations

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

2012 • 98 citations

HGF Protects Corneal Epithelial Cells from Apoptosis by the PI-3K/Akt-1/Bad- but Not the ERK1/2-Mediated Signaling Pathway

2004 • 73 citations

Genetics and epigenetics of cutaneous malignant melanoma: A concert out of tune

2012 • 69 citations

The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance

2012 • 58 citations

Virus, cells and videotape

2002 • 37 citations

Cake: a bioinformatics pipeline for the integrated analysis of somatic variants in cancer genomes

2013 • 30 citations

Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer

2010 • 29 citations

Association of MITF and other melanosome-related proteins with chemoresistance in melanoma tumors and cell lines

2013 • 24 citations

Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells

2010 • 17 citations

Role of the ERas gene in gastric cancer cells

2013 • 15 citations

ERas enhances resistance to CPT-11 in gastric cancer.

2011 • 15 citations

Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors

2013 • 8 citations