The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2010 • 3,500 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

2010 • 2,120 citations

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

2012 • 1,880 citations

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

2008 • 1,820 citations

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

2010 • 1,729 citations

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

2010 • 1,438 citations

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

2010 • 1,404 citations

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

2011 • 1,378 citations

BRAF mutation predicts sensitivity to MEK inhibition

2005 • 1,312 citations

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

2008 • 1,305 citations

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

2010 • 1,218 citations

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

2006 • 1,193 citations

BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

2005 • 1,152 citations

BRAFMutations in Hairy-Cell Leukemia

2011 • 975 citations

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

2011 • 964 citations

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

2006 • 846 citations

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

2011 • 777 citations

MEK1 mutations confer resistance to MEK and B-RAF inhibition

2009 • 622 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

The role of Bcl-2 family members in tumorigenesis

2003 • 536 citations

Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases

1999 • 518 citations

Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma

2008 • 500 citations

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

2012 • 495 citations

Tumour cell survival signalling by the ERK1/2 pathway

2008 • 455 citations

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

2010 • 444 citations

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

2011 • 396 citations

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1

2010 • 341 citations

BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation

2010 • 340 citations

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

2008 • 203 citations

Amplification of the Driving Oncogene, KRAS or BRAF , Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

2011 • 201 citations

Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1

2007 • 190 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

2003 • 172 citations

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

2007 • 169 citations

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY‐142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

2009 • 141 citations

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

2010 • 136 citations

Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis

2006 • 119 citations

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak

2011 • 107 citations

Mechanisms of acquired resistance to ERK1/2 pathway inhibitors

2012 • 107 citations

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF-β–Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4

2009 • 104 citations

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene‐targeted therapeutics

2009 • 94 citations

ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

2004 • 86 citations

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs

2010 • 74 citations

Blockade of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase and Murine Double Minute Synergistically Induces Apoptosis in Acute Myeloid Leukemia via BH3-Only Proteins Puma and Bim

2010 • 67 citations

Colorectal cancer cells with the BRAFV600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

2008 • 65 citations

Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik

2012 • 52 citations

Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes

2006 • 46 citations

ARC Synergizes with ABT-737 to Induce Apoptosis in Human Cancer Cells

2010 • 18 citations